The Ministry of Health of China issued the Implementation Plan for Expanding the National Immunization Program.

　　BEIJING, Feb. 19 (Xinhua) According to the website of the Ministry of Health, in order to implement the goals and tasks of expanding the national immunization program, the Ministry of Health organized and compiled the Implementation Plan for Expanding the National Immunization Program (hereinafter referred to as the "Plan").


　　Expand the implementation plan of national immunization program


　　In order to implement the spirit of "expanding the scope of national immunization program, including 15 infectious diseases that can be effectively prevented by vaccination, such as hepatitis A and meningitis" put forward by Premier Wen Jiabao at the Fifth Session of the Tenth National People’s Congress, implement the objectives and tasks of expanding national immunization program, standardize and guide the scientific implementation of expanding national immunization program in various places, and effectively prevent and control related infectious diseases, this program is formulated.


　　I. Principles


　　The expansion of the national immunization program is implemented in accordance with the principle of "emphasizing key points, guiding by classification, paying attention to actual results and implementing step by step".


　　Second, the content


　　(1) On the basis of the six kinds of national immunization plan vaccines currently used nationwide, such as hepatitis B vaccine, BCG vaccine, polio vaccine, DTP vaccine, measles vaccine and DTP vaccine, the cell-free DTP vaccine is used to replace DTP vaccine, and hepatitis A vaccine, epidemic cerebrospinal meningitis vaccine, Japanese encephalitis vaccine and measles vaccine are included in the national immunization plan, and regular vaccination is carried out for school-age children.


　　(2) Vaccinate key populations with hemorrhagic fever in key areas; When anthrax and leptospirosis occur or floods may lead to the outbreak of leptospirosis, emergency vaccination of anthrax vaccine and leptospirosis vaccine shall be carried out for key populations.


　　Fifteen infectious diseases, such as hepatitis B, tuberculosis, poliomyelitis, whooping cough, diphtheria, tetanus, measles, hepatitis A, epidemic cerebrospinal meningitis, Japanese encephalitis, rubella, mumps, epidemic hemorrhagic fever, anthrax and leptospirosis, can be prevented by vaccination.


　　III. Objectives


　　(a) the overall goal.


　　Fully implement the expanded national immunization program, continue to be polio-free, eliminate measles, control hepatitis B, and further reduce the incidence of vaccine-preventable infectious diseases.


　　(2) Work indicators.


　　1. By 2010, the vaccination rate of school-age children with hepatitis B vaccine, BCG vaccine, polio vaccine, DTP vaccine (including DTP vaccine) and measles vaccine (including leprosy vaccine, measles vaccine and measles vaccine) will reach more than 90% in rural areas.


　　2. By 2010, epidemic cerebrospinal meningitis vaccine, Japanese encephalitis vaccine and hepatitis A vaccine will be popularized nationwide for school-age children.


　　3. The vaccination rate of the target population of hemorrhagic fever vaccine reached more than 70%.


　　4 anthrax vaccine, leptospirosis vaccine emergency vaccination target population vaccination rate reached more than 70%.


　　IV. Inoculation requirements


　　(1) Vaccination time.


　　1. Hepatitis B vaccine


　　Three doses, one dose at birth, one month old and six months old, and the first dose should be inoculated as soon as possible within 24 hours after birth.


　　2. BCG


　　Inoculate 1 dose, and vaccinate children at birth.


　　3. Polio vaccine


　　Inoculate 4 times, and children aged 2 months, 3 months, 4 months and 4 years old are inoculated 1 time each.


　　4. DTP vaccine


　　Inoculate for 4 times, one time for children aged 3 months, 4 months, 5 months and 18-24 months respectively. The immunization program of cell-free DTP vaccine is the same as that of DTP vaccine. At the stage of insufficient supply of cell-free DTP vaccine, the cell-free DTP vaccine is used to replace DTP vaccine in the order from the fourth dose to the first dose; The insufficient part continues to use DTP vaccine.


　　5. DTP vaccine


　　Inoculate 1 dose, when children are 6 years old.


　　6 measles vaccine (leprosy, measles vaccine)


　　At present, at the stage of insufficient supply of measles vaccine, the transitional immunization program with measles vaccine is used. One dose of leprosy vaccine was inoculated at the age of 8 months, and measles vaccine continued to be used for the part with insufficient leprosy vaccine. 18-24 months old, one dose of measles vaccine was inoculated, the insufficient part of measles vaccine was replaced by measles vaccine, and the insufficient part of measles vaccine continued to be used.


　　7. meningococcal vaccine


　　Inoculate 4 doses, children aged 6-18 months with 2 doses of group A meningococcal vaccine, and children aged 3 years and 6 years with 1 dose of group A+C meningococcal vaccine respectively.


　　8. Japanese encephalitis vaccine


　　Live attenuated Japanese encephalitis vaccine was inoculated twice, and children aged 8 months and 2 years old were inoculated once each. Inactivated Japanese encephalitis vaccine was inoculated 4 times, 2 times for children aged 8 months, and 1 time for children aged 2 years and 6 years respectively.


　　9. Hepatitis A vaccine


　　Live attenuated hepatitis A vaccine was inoculated once, and children were vaccinated at the age of 18 months. Inactivated hepatitis A vaccine was inoculated twice, and children aged 18 months and 24-30 months were inoculated once each.


　　10. Hemorrhagic fever vaccine


　　Inoculate 3 doses, the second dose 14 days after the first dose, and the third dose 6 months after the first dose.


　　11. Anthrax vaccine Anthrax vaccine is inoculated once, and it is inoculated in the event of an anthrax epidemic. Direct contacts and patients of cases or sick animals cannot be vaccinated.


　　12. Leptospira vaccine is inoculated with 2 doses, and the recipient is inoculated with the second dose 7-10 days after the first dose. See the attached table for vaccine immunization procedures.


(2) vaccination targets.


　　1. According to the immunization program, all school-age children who have reached the age of the month (year) should be vaccinated.


　　2. The vaccine newly incorporated into the national immunization plan is targeted at children who have reached the age of each dose specified in the immunization program from the specified implementation time.


　　3. The vaccination targets of intensive immunization are determined according to the implementation plan of intensive immunization.


　　4. Hemorrhagic fever vaccination is the target population aged 16-60 in key areas.


　　5 anthrax vaccination targets are indirect contacts of anthrax cases or sick animals and high-risk groups around epidemic spots.


　　6. Leptospira vaccination targets are high-risk groups aged 7-60 who may be exposed to epidemic water in epidemic areas.


　　V. Scope of implementation


　　(1) Expand the national immunization program to cover 31 provinces, autonomous regions, municipalities directly under the Central Government and Xinjiang Production and Construction Corps.


　　(two) hepatitis B, BCG, polio, DTP, meningitis, DTP and other vaccines are implemented nationwide.


　　(3) JE vaccine shall be fully implemented in other provinces, autonomous regions and municipalities directly under the Central Government except Tibet, Qinghai, Xinjiang and Xinjiang Production and Construction Corps. Whether Tibet, Qinghai, Xinjiang and Xinjiang Production and Construction Corps carry out JE vaccination shall be determined by the above-mentioned regional health bureaus and reported to the Ministry of Health.


　　(IV) Hepatitis A vaccine, measles virus, acellular pertussis, etc. cannot meet the vaccination of all school-age children for the time being, and the provincial health administrative department (including the Health Bureau of Xinjiang Production and Construction Corps, the same below) selects the implementation area and the implementation object according to the annual central special fund arrangement plan, the epidemic situation of diseases and the feasibility of implementation. With the increase of vaccine supply, the scope of implementation will be gradually expanded.


　　(five) the scope of implementation of the polio vaccine and measles vaccine shall be determined according to the implementation plan of the supplementary immunization.


　　(six) hemorrhagic fever vaccine according to the epidemic situation to determine the implementation of the province. Anthrax vaccine and leptospirosis vaccine shall be inoculated in case of anthrax and leptospirosis epidemic or flood disaster which may lead to leptospirosis outbreak.


　　VI. Implementation Measures


　　(1) Strengthen leadership and organize the implementation of the expanded national immunization program.


　　Local health administrative departments at all levels should take the implementation of the expanded national immunization program as the current focus and earnestly strengthen leadership. It is necessary to formulate a specific implementation plan for expanding the national immunization program in this region, and under the leadership of the local people’s government, in conjunction with relevant departments such as finance, development and reform, education, food and drug supervision, organize and implement the work of expanding the national immunization program.


　　(two) extensive publicity to raise public awareness of expanding the national immunization program.


　　We should give full play to all social forces, make full use of radio, television, newspapers, internet and other forms, vigorously publicize the policies and achievements of the national immunization program, and the significance of implementing immunization programs to protect public health. Carry out regular publicity and "4.25" vaccination day publicity activities, widely popularize vaccination knowledge, improve the enthusiasm and initiative of the whole society to participate in the national immunization program, and create an atmosphere for the whole society to participate in the implementation of the national immunization program.


　　(3) Strengthen team building and improve the ability to implement the national immunization program.


　　Local health administrative departments at all levels should, according to the task of expanding the national immunization program, strengthen the construction of institutions and teams related to immunization program, rationally plan and set up vaccination units, and adjust and enrich immunization program professionals and grassroots vaccination personnel. Make a training plan, do a good job in the training of immunization planning professionals, grassroots vaccinators and relevant personnel of medical institutions, and improve their professional level and service ability. Disease prevention and control institutions at all levels should strengthen the technical guidance for the implementation of the expanded national immunization program.


　　(four) improve the form of immunization services, standardize vaccination behavior, improve the quality of immunization services.


　　According to the contents and requirements of expanding the national immunization program, combined with the local actual situation, we should adjust the forms of immunization services and increase the number of services to ensure that school-age children receive vaccination services in time. Strengthen the management of vaccination services, and carry out vaccination in strict accordance with the relevant provisions of the Code of Practice for Vaccination and the new immunization procedures. Strengthen the vaccination work of remote and poor areas and floating children, and strive to improve the vaccination rate. Actively cooperate with the education department to do a good job in the inspection of children’s nursery and school vaccination certificates. Accelerate the construction of information management system for children’s vaccination, and provide information support for the implementation of the expanded national immunization program.


　　(five) to strengthen the construction of cold chain, to ensure the national immunization program vaccine cold chain operation.


　　It is necessary to expand the cold chain capacity according to the needs of expanding the national immunization program, and improve the mechanism of cold chain construction, supplement and renewal. Disease prevention and control institutions and vaccination units should strictly implement the cold chain operation of vaccines in accordance with the requirements of the "Regulations on the Management of Vaccine Storage and Transportation" and do a good job in the cold chain monitoring and management of all aspects of the storage, transportation and use of vaccines under the National Immunization Program.


　　(six) strictly regulate the use and management of special funds.


　　Use the special funds for expanding the national immunization program in strict accordance with the regulations on the management of special funds for public health to ensure earmarking. Effectively strengthen the registration, use and management of vaccines and syringes, and timely allocate vaccination subsidies for rural doctors and other preventive and health care personnel. All provinces, autonomous regions, municipalities directly under the Central Government and Xinjiang Production and Construction Corps will report the annual demand plan for vaccines and supporting syringes for the next year to China Center for Disease Control and Prevention before the end of October each year. China Center for Disease Control and Prevention summarized and reported to the Ministry of Health. The selection and procurement methods of vaccine varieties for expanding the national immunization program shall be implemented in accordance with the relevant provisions of the Ministry of Health and the Ministry of Finance.


　　Seven, supervision and evaluation


　　Local health administrative departments at all levels should regularly organize supervision and evaluation of the implementation of the expanded national immunization program within their respective jurisdictions, formulate scientific supervision and evaluation plans, carry out regular supervision and evaluation activities step by step at the provincial, municipal and county levels, find problems in time and solve them, and urge and guide all measures to be implemented. The Ministry of Health will regularly assess and evaluate the implementation of national immunization programs in various places.


Editor: Yin Wei

The merger and acquisition of local pharmaceutical giants has entered a high-frequency period： the key to the competition for large varieties of drugs

"China’s pharmaceutical industry is rapidly approaching mature markets, and I wouldn’t be surprised if there are 10 to 20 such large-scale mergers and acquisitions in the next year or two. Because of consistency evaluation, drug varieties will play an increasingly important role in the logic of mergers and acquisitions. " A few days ago, Lin Jianghan, a partner of Roland Berger’s pharmaceutical and medical business, said in an interview with China Business News.

In the past week, three large-scale pharmaceutical mergers and acquisitions came to an end. Behind these three mergers and acquisitions of giant pharmaceutical companies, the desire of local pharmaceutical companies for large varieties of high-quality drugs jumped to the paper, followed by the annual increase in transaction volume and the rising transaction price.

Throw out 3 billion a day

On May 21st, Shanghai Pharmaceutical (601607.SH) (hereinafter referred to as "Shanghai Pharmaceutical") announced that it had invested 144 million US dollars (equivalent to about 915 million yuan) to acquire 100% equity of Takeda Chromo Beteiligungs AG, a wholly-owned Swiss subsidiary of Takeda, thus indirectly holding 26.34% equity of Guangdong Tianpu Biochemical Pharmaceutical Co., Ltd. After the completion of this transaction, the equity of Tianpu held by Shanghai Pharmaceutical Co., Ltd. will rise from 40.80% to 67.14%, achieving absolute control. On the same day, the reorganization plan of Hainan Haiyao (000566.SZ), another pharmaceutical listed company, was officially released. The company plans to purchase 100% shares of Qili Pharmaceutical at a price of more than 2.1 billion yuan.

In just one day, 3 billion funds were thrown out and two pharmaceutical companies were merged.

In fact, since May, the number of large-scale mergers and acquisitions in the pharmaceutical industry has surged. On May 18th, China Resources Pharmaceutical (03320.HK) Group announced that it would realize the absolute control of Jiangzhong Pharmaceutical (600750.SH) by purchasing part of the equity and increasing capital by cash or assets. According to the 2017 annual report of Jiangzhong Pharmaceutical Group, Jiangzhong Pharmaceutical achieved annual revenue of 1.747 billion yuan, a year-on-year increase of 11.83%; Among them, the over-the-counter drug business revenue was 1.457 billion yuan, accounting for 83.4%. In the product layout of Jiangzhong Pharmaceutical, Jiangzhong Compound Caoshanhu Buccal Tablets, Jiangzhong Jianwei Xiaoshi Tablets and Jiangzhong Liangsheng Tablets are its fist products, and the market share of Jianwei Xiaoshi Tablets reaches 70%, ranking first in the industry. According to the analysis of insiders, China Resources will not only obtain several high-quality varieties, but also further enhance the regional advantages of self-operated products in Jiangxi.

"In the future, the pharmaceutical industry in China will be further integrated, and the window of mergers and acquisitions will be opened. Such large-scale mergers and acquisitions will continue to occur." Lin Jianghan said, "On the other hand, the strong alliance between local pharmaceutical companies is also becoming a new trend."

In his view, in this wave of mergers and acquisitions, the subject of high-quality varieties has become a hot spot for competition. An insider of Shanghai Pharmaceutical Co., Ltd. previously revealed to the First Financial Reporter that in recent years, according to Shanghai Pharmaceutical Co., Ltd.’ s current strategy of focusing on large varieties, mergers and acquisitions will still focus on varieties. "The main thing is to see how valuable this variety is in its field, such as whether it is an exclusive variety, whether there are opportunities in this field of the whole market, how much market share it occupies, and whether it is growing well." The insider revealed.

Taking the acquisition of Tianpu by Shanghai Pharmaceutical Co., Ltd. as an example, Tianpu’s two core products "Tianploan" and "Kailikang" are large varieties with sales scale exceeding 1 billion and 300 million years respectively. At present, there are 28 products with annual sales revenue exceeding 100 million, including one with sales revenue exceeding 800 million and five with sales revenue exceeding 400 million. The addition of Tianpu will directly promote the birth of over 1 billion varieties of Shanghai medicine.

On the same day, Qili Pharmaceutical, the target of Hainan Haiyao’s merger and acquisition, also has an attractive drug variety line: it includes 108 drug varieties with a total of 216 drug production approval numbers, and 184 products listed in the national or local medical insurance catalogue, including 135 products listed in the national medical insurance catalogue.

"Consistency evaluation will further promote the integration between pharmaceutical industries, and many of these integrations occur through mergers and acquisitions, resulting in stronger ones." Lin Jianghan said, "Some powerful enterprises such as China Resources, Shanghai Pharmaceutical and Sinopharm can expand their product lines through mergers and acquisitions. For example, China Resources’ acquisition of Jiangzhong can further consolidate its product line of proprietary Chinese medicines and improve its health care products."

In Lin Jianghan’s view, in the past two years, the competition in the domestic pharmaceutical market has been fierce, and many factors, including consistency evaluation and medical insurance price reduction, have had a serious impact on pharmaceutical companies in the short term. The days of relying on a single variety to achieve substantial profits are gone forever, so domestic pharmaceutical companies are aiming at overseas mergers and acquisitions in the hope of broadening their profit channels.

Variety competition spread overseas

In the eyes of Sun Chao, PwC’s partner in Eliot’s medical business, this case with the logic of variety competition for M&A does not only occur in the mutual M&A between local pharmaceutical companies, but also in overseas markets. Good varieties have also become the object of competition among major local pharmaceutical companies. In his view, some products that are at the back end of the product line in multinational pharmaceutical companies still have a lot of room for development when they are placed in China.

"Foreign pharmaceutical companies have products in their hands, but sometimes these products are not in key areas. For them, marketing also needs resources, and the cost of simply developing channels in the China market is not small. Local pharmaceutical companies have the ability to sell drugs in China. After the varieties are bought back, the value of these drugs can be redeveloped, and the value can be reflected. " Sun Chao said.

On May 8th, Luye Pharmaceutical (02186.HK), a Hong Kong-listed company known as the "global buyer" in the local pharmaceutical circle, announced that it had obtained the license rights of AstraZeneca and Sruikang sustained-release tablets for US$ 546 million (about RMB 3.477 billion). Sirecan and Sirecan sustained-release tablets are atypical antipsychotic drugs with antidepressant properties developed by AstraZeneca. They were first listed in Britain in July 1997, approved by FDA in the United States in September of the same year, and listed in China in 2001. According to public information, Serricone was once AstraZeneca’s second best-selling drug. At present, it has been listed in more than 80 countries around the world, with more than 10 million prescriptions.

In fact, although Sirecan was once one of AstraZeneca’s best-selling drugs with a prescription of more than 10 million, as a mature variety, its sales decline was almost inevitable after losing patent protection. However, in the view of Luye, Siruikang entered the national medical insurance catalogue in 2009, and its sustained-release tablets entered the national medical insurance catalogue through negotiations in 2017. Although the patent of Siruikang ordinary tablets has expired, the sustained-release tablets are still exclusive varieties in some areas and are still in the patent protection period in some markets. More importantly, the sustained-release tablets have barriers to preparation process and clinical data protection period, and have maintained a good market structure even in the market that has lost patent protection.

According to the data provided by AstraZeneca, the total sales of Siricon series products in 51 designated countries and regions acquired by Luye Pharmaceutical is about 148 million US dollars, and the operating profit after deducting manufacturing costs and sales expenses is about 110 million US dollars. Among them, the sales of Siruikang ordinary tablets in 2017 was about 85 million US dollars, and the sales of sustained-release tablets were about 63 million US dollars.

"Based on the operating profit of 110 million yuan last year, the transaction consideration is less than 5 times and the valuation is very reasonable." Jiang Hua, vice president of Luye Pharmaceutical, said in the subsequent investor exchange conference call, "AstraZeneca’s strategic focus shift has led to its marketing expenses in Siruikang not being active, and the potential of some markets has not been tapped. We believe that as a first-line drug for schizophrenia, Siruikang still has good growth prospects in the future. "

For Luye Pharmaceutical, the central nervous system is one of the four key areas of its business layout. At present, this area contributes more than 10% of the company’s sales. After the acquisition of Siruikang, it can further enrich the existing central nervous system product portfolio of Luye Pharmaceutical, not only occupying the China market, but also entering the broad international market, which is expected to make central nervous system drugs account for 30% of the group’s income.

In 2017, Sanpower Group made a sensation by announcing the acquisition of 100% equity of Dendreon, an American biopharmaceutical company. Dendreon is the owner of Provenge, the world’s first cellular immunotherapy for prostate cancer. Although Sanpower Group is not a pharmaceutical company, it is the first time that a China company has acquired an original American drug, and the acquisition amount of 819 million US dollars (about 5.7 billion yuan) is also a record for a China company.

"China local pharmaceutical enterprises ‘ Go to sea ’ The upsurge of product acquisition will continue, especially for those products that have passed the patent protection period. Such product acquisition can make up for the shortcomings of its own product line relatively quickly. After all, relying on its own research and development is not so effective. " Sun Chao said, "Whether it is a local enterprise or a multinational group, focusing on the core treatment field has almost become the common choice and investment logic of pharmaceutical giants in the context of the decreasing input-output ratio of innovative drugs."

Consistency evaluation into a merger booster

"There are too few good varieties on the market. Who doesn’t want good varieties and who wants to sell them? Considering the company’s own positioning and development needs, it is more difficult to find suitable varieties. Sometimes, the more mature the company, the more difficult it is to receive good varieties, and it depends on opportunities. " Previously, the R&D director of a large pharmaceutical company complained to the First Financial Reporter.

In fact, the logic of merger and reorganization oriented by variety acquisition has been recognized by domestic pharmaceutical companies in recent years, especially in the context of slow drug review, long research and development cycle of new products, high investment and high risks. Direct acquisition of ready-made varieties has become a shortcut for enterprises to enrich their product lines and integrate industry resources. However, many insiders revealed that a few years ago, the willingness to "sell themselves" was not strong, but in the past two years, with the implementation of the new GMP certification and the continuous promotion of consistency evaluation, many small and medium-sized pharmaceutical enterprises have struggled to survive, and more and more companies with high-quality varieties have begun to waver.

In November, 2015, china food and drug administration published "Opinions on Carrying out Consistency Evaluation on the Quality and Efficacy of Generic Drugs (Draft for Comment)" (hereinafter referred to as "Opinions"), which stated that some generic drugs need to complete consistency evaluation before the end of 2018, and those who fail will be cancelled the approval number of drugs.

The vice president of a well-known domestic generic pharmaceutical company revealed to CBN that due to the consistency evaluation, the enterprise has to go through all the procedures when applying, and each drug is equivalent to reapplying for a document number. According to the current situation, the average capital consumption of each variety is not less than 3 million, which is a huge challenge for pharmaceutical companies, both in terms of manpower and financial resources.

"For some companies that are not strong but have good varieties, it is possible to choose to sell at this time." Lin Jianghan, partner of Roland Berger’s pharmaceutical and medical business, revealed.

The resulting number of pharmaceutical mergers and acquisitions is increasing year by year. According to the previous statistics of Zero2IPO Group, among the 222 M&A cases from 2011 to December 31, 2017, the number of M&A cases increased significantly after 2015, reaching a new high in 2017, with 56 M&A cases in the pharmaceutical circle. In terms of the amount of mergers and acquisitions, it also showed a significant growth trend after 2015. In 2017, the amount of mergers and acquisitions involved reached 12.709 billion yuan.

Many people in the industry said that through mergers and acquisitions, becoming bigger and stronger as a group leader, or taking the road of internationalization through import registration, "exporting to domestic sales" will become a one-time evaluation opportunity for the industry leaders such as Sinopharm, Shanghai Pharmaceutical and Fosun.

"In the domestic pharmaceutical circulation industry, Sinopharm, Shanghai Pharmaceutical Co., Ltd. and China Resources are in a three-legged position, but at present, their net profit margins are all low, so they usually act as agents for the products of some pharmaceutical companies for integrated marketing, and the best solution to improve the net profit margin is to directly expand their own product lines." Wang Xin, President of Jost Sullivan Greater China, said in an interview with China Business News.

Therefore, out of the desire for good products, consistency evaluation brings opportunities for deep cooperation between Chinese and foreign enterprises on the other hand.

"For pharmaceutical companies in China, if a foreign-funded original drug research company is willing to provide information on drug ingredients, production processes and preparations, it is equivalent to getting ‘ Secret recipe ’ . China generic drug production has been ‘ Imitate medicine only, not the process, process and crystal form ’ Difficult problems, although we know the chemical composition information of the original drug, we don’t pay enough attention to the key technical nodes such as excipients, production technology, quality control process and compound crystal form. For foreign-funded enterprises, it is not easy to sell generic drugs into hospitals in China, which requires resources accumulated by local pharmaceutical companies for a long time. " Shi Lichen, founder of Beijing Dingchen Management Consulting Co., Ltd. analyzed, "Foreign-funded original drug research enterprises can exchange data information for shares, and local enterprises are responsible for production and sales, so that foreign-funded enterprises can still share the China market, and local enterprises can also get learning and production opportunities."

"I believe that such mergers and acquisitions will rise in the order of magnitude in the future. There are 5,000 pharmaceutical companies in China, including 3,000 chemical medicine companies and 2,000 Chinese patent medicine companies, among which there is a lot of room for mergers and acquisitions. Among them, small enterprises with weak strength will face the risk of being shut down and annexed, and large-scale regional mergers and acquisitions such as China Resources’ acquisition of Jiangzhong Pharmaceutical will certainly happen in the future. " Lin Jianghan said.

The M8 will be launched in April, with a pre-sale price of 368,000 units and a small order of more than 70,000 units in two weeks.

[car home] ] On March 20th, at Huawei Pura Pioneer Festival and HarmonyOS Zhixing New Product Launch Conference, Yu Chengdong, managing director of Huawei, chairman of terminal BG and chairman of smart car solution BU, said that the pre-sale of (|) had started on March 6th, with the pre-sale price of 368,000 yuan, and the small order quantity had exceeded 70,000 units in two weeks. At the same time, the car will be launched in April.

Home of the car

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Wenjie M8 is positioned as a medium and large-sized extended-range SUV, with the length, width and height of 5190/1999/1795mm and the wheelbase of 3105mm, which is 40mm shorter than that of Wenjie M9 and 5mm less than the wheelbase. Like the M9, the car is also available in 5-seat and 6-seat versions. In terms of power, its CLTC pure electric cruising range is longer, with 201km and 310km optional, and its comprehensive cruising range is 1405km and 1526km respectively. Front and rear double motors +1.5T range extender, and the comprehensive power of the system is 392kW. Highlights of the new car include triple screen in the car, Huawei HarmonyOS cockpit, Huawei advanced intelligent driving, Xuanwu hard-core body and Huawei Turing platform.

Home of the car

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Home of the car

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The official also revealed that M9 will upgrade Huawei ADS 4 Smart Drive in the third quarter of this year. At the same time, as of March 19th, 2025, HarmonyOS Zhixing has delivered a total of 680,000 vehicles, and avoided more than 1.62 million possible collisions. For more information about the brand, we will continue to pay attention. (Text/car home Zhouyi)

The length of the car is five meters, the wheelbase is three meters, and the starting price of the new Lincoln Navigator is more than 1 million.

Auto-First | Wu Yun

Key points first: the new Navigator L Long Axis President Edition is priced at 1.298 million yuan, the new Navigator MONO Limited Edition MONO WHITE is priced at 1.113 million yuan, and the cheapest new Navigator MONO Limited Edition is priced at 1.108 million yuan, and the country is limited to 63 units.

How big is the new Navigator L long axle version? It is over 5.6 meters long and has a wheelbase of over 3.3 meters.

Born in 1997, it not only created the full-size luxury SUV market segment on a global scale, but also deepened the ultimate connotation of American luxury and became a gift masterpiece for the new century. With more than 20 years of poise and heroic strength, it is still an outstanding representative in this field, and it is also the top choice for full-size luxury SUVs.

"As the flagship model of the SUV family, it is popular with many customers in China, and many fans have come to know and fall in love with this American luxury brand that keeps pace with the times," said Mao Jingbo, China president. "The launch of the new long-axis version and the new MOMO limited edition will bring customers more personalized product choices and further strengthen their position as the market leader in this segment."

The new long-axis version is based on the new upgrade, combining the domineering appearance of the leader, the spacious and luxurious interior space, the unrivaled power combination and the leading and easy-to-use technology configuration, once again pushing the peak land travel experience to a new height. The new long-axis version sits on the "Eight Navigators", continuing the market benchmark of full-size luxury SUVs.

Since its inception, it has stood out among the crowd with its burly figure. The new car leads the class with a length of 5,355mm and a wheelbase of 3,112mm, while the new long axis version lengthens the "pilot" on this basis: the car length is 5,657mm, the width is 2,073mm, the height is 1,934mm, and the wheelbase reaches 3,342mm, which refreshes the best in the same class. The magnificent and atmospheric body integrates smooth and elegant lines, highlighting the outstanding bearing of the leader.

At the same time, the new long-axis version of the majestic body contains more open and comfortable space. When the industry is still discussing how to improve the riding experience of the second row of vehicles, the luxury space of the third row has conquered the market. The three-row seven-seat layout allows every passenger to enjoy a respectful riding experience comparable to first class.

The new long-axis version also has the largest luggage compartment volume in its class: with a standard volume of 722 liters in the three-row seat mode, the whole family no longer needs to worry about storing luggage for daily travel; the second and third rows of seats also support one-button electric folding. When the second and third rows of seats are all laid down, the luggage compartment capacity can reach an amazing 2,947 liters, meeting any storage needs of the whole family. In addition, the oversized panoramic sunroof with an area of 1,200mm x 870mm is also the first in its class. When the warm sun shines into the car, the new long-axis version is transformed into a mobile luxury sun room.

The new long-axle version has a domineering appearance and high recognition. The star-shaped front grille guards the century-old star in the middle with an exquisite shield pattern, which complements the collection of Knight Star logos on the front of the hood and on both sides of the vehicle’s C-pillar. The unique "L" logo on the rear highlights the unique identity of the new long-axle version.

The new long-axis version is equipped with crown-style LED adaptive headlights and double Ice Hockey stick-style LED daytime running lights, which combine with the front face shape to present an enterprising and calm temperament. The one-piece through-the-wheel LED taillights that once led the industry’s design vane not only enhance night driving safety, but also make the vehicle’s back wider. In addition, the new long-axis version uses 22-inch 21-piece high-grade aluminum alloy wheels inspired by the turbofan fins of aircraft engines, and the angular shape helps to "pilot" the aura. Electric telescopic foot pedals allow every passenger to enjoy a personable on and off experience.

The new long-axis version continues the family’s excellent "pilot" power configuration, equipped with a 3.5-liter V6 twin-turbo engine, which can burst out a maximum power of 387 horsepower and a peak torque of 680 Nm. The unique 10-speed automatic transmission in the same class has a tighter gear ratio, reducing the shift speed difference between gears, making acceleration smoother and reducing fuel consumption. The non-load-bearing body structure combined with the lightweight high-density aluminum body allows the vehicle to reduce weight while improving body rigidity and handling flexibility, giving the vehicle better fuel economy, safety and handling.

The new long-axis version of the OurHours four-wheel drive system integrates an eLSD electronic non-slip differential, CCD adaptive suspension and EPAS electronic power steering system, making the driving experience more confident and unhurried. In addition, the driving control system offers six driving modes including standard, energy-saving, sports, slippery, complex road conditions and low-speed hill climbing.

The brand new one has won the 2018 "Ward’s Ten Best Interiors" award. The new long-axis version of the interior follows the design language of the "Horizon Principle" of Quiet Journey, bringing luxurious materials and ultimate comfort.

When the viewing angle is bounded by the horizon, the line in front of the cockpit runs from left to right across the instrument panel and center control screen, and finally reaches the front of the passenger seat, allowing the line of sight to be open and balanced. The unique piano-key electronic key shift and the piano paint of the center console complement each other, showing an extraordinary artistic atmosphere.

The interior is made of Venetian top-grade natural leather produced by Eagle Ottawa in the United States, which is soft and rich to the touch. With elegant solid wood carving, it highlights the exquisite interior design and craftsmanship. The whole car has a wealth of humanized storage space. The front suspension three-dimensional storage space divides the center console into upper, middle and lower three layers, making it more convenient to store personal belongings. The exclusive full-body seat with 30-way electric adjustment and massage function can provide front passengers with all-round adjustment including seat cushions, seat backs, waist rests and heads, and can also adjust the seat cushions supporting the legs individually. No matter what body shape, you can find a comfortable sitting position that fits you perfectly. The new long-axis version is equipped with a Revel ? Ultima TM top-of-the-line sound system with 20 speakers, using Quantumlogic and Clari-FiTM intelligent sound source restoration technology to bring the auditory enjoyment of a VIP seat in the theater to all passengers.

Rich humanized technology configuration is an important part of American luxury, the new long axis version is the master of this aspect, with a number of leading technology implementation of new technology "pilot".

The new long-axis version is equipped with a 12.3-inch full digital instrument cluster and a 10-inch touch LCD display. The HUD head-up display function uses DLP technology only used in high definition theaters, which can process images at thousands of times per second, while supporting personalized customized content, so that drivers can view speed, navigation, calls and other information without lowering their heads. In-car Wi-Fi and wireless charging of mobile phones allow you to stay connected to the world anytime, anywhere.

Based on the high requirements of Chinese customers for air quality and travel health, the new long-axis version is equipped with the Auto Air Refresh "Fresh Air Butler" function specially developed for the Chinese market, which integrates the air monitoring system in the car with the air purification system, and also supports real-time display of the air quality level inside and outside the car on the central control screen or the "Way" APP 1.

"Fresh Air Butler" adopts a high-efficiency activated carbon filter with a quadruple filter structure, including: pre-filter layer, microfiber layer, activated carbon layer and support layer, which can effectively filter 96% of PM1.0 and PM2.5, 94% of PM0.3 particulate matter 2, and can absorb harmful substances including n-butane, toluene and nitrogen oxides to prevent odors from entering the car. Turning on the air circulation external during driving is like adding a layer of "protective cover" to the vehicle. At the same time, the OAQS extravehicular air quality monitoring system can monitor the air quality3 in real time, and can automatically switch to the air domestic circulation mode when necessary, which can effectively reduce the exhaust gas generated by the dense areas of vehicles such as urban tunnels and elevated roads into the car, protecting your breathing safety.

"Fresh Air Butler" also includes three functions: cockpit fresh air, unlocked fresh air 4 and parking fresh air 4. The cockpit fresh air function will automatically turn on the air external circulation after the vehicle is started. When the vehicle is in the air domestic circulation mode for a long time, it will automatically switch the external circulation mode. The unlocked fresh air function can be activated by unlocking the vehicle with the key, and the air conditioning system sends fresh air outside the car into the car at the maximum wind speed for about 1 minute. The parking fresh air function is controlled by a timer. The vehicle will automatically start after being turned off for 2 hours, and the air in the car will be refreshed within 1 minute. It will automatically start every 2 hours. If you stop for more than 6 hours, you can start up to 3 times. " A series of functions silently protect the respiratory health of drivers and passengers, intelligently switch the internal and external air circulation, and become a real "health steward" on the road.

In terms of driving safety, the new long-axis version is equipped with the Co-Pilot 360TM intelligent driving assistance system, which integrates more than 20 user-friendly driving assistance configurations, including the ACC intelligent adaptive cruise control system with intelligent cruise control and Stop & Go automatic follow-up function, and the PCA anti-collision warning system with pedestrian monitoring and active emergency braking function, which can help drivers actively brake to low-risk speed or full braking in emergency situations. At the same time, the LDW lane departure warning system and the LKA lane keeping assistance system will prompt and automatically correct the vehicle once it detects that the vehicle has deviated from the lane. In addition, there are 360-degree panoramic image viewing system, active parking and departure assistance, Auto Hold automatic parking, HSA ramp assistance and HDC steep slope slow descent and other rich and comprehensive safety configurations to help you ride with peace of mind all the way.

Joining forces with The Pantone Color Institute, an authority in the field of color and the definer of global color trends, to create the strongest aesthetic trend in 2020, directly attacking the visual subversion of the perception, giving the new MONO limited edition two exclusive color schemes: the deep MONO BLACK and the atmospheric MONO WHITE, showing the timeless classic through black and white two-color design, highlighting the unique taste, and bringing the unique aesthetic sense of timeless fashion to Chinese customers.

At the same time, the new MONO limited edition also continues the brand’s innate fashion genes, creating a unique American luxury. Chic decorations such as blackened wheels, the same-colored grille on the body, surround and side logos reveal exclusivity in the details, and condense classics in the bits, highlighting the unique taste of every car owner. And the collection Knight Star logo on the front of the hood adds infinite feelings and heritage to the vehicle.

The latest news of Jason Wu’s physical condition.

Jason Wu is in good health and devoted himself to filming new films.

In recent online rumors, the famous filmmaker Jason Wu was sent to hospital, which caused widespread concern and concern among fans. However, Jason Wu’s studio quickly denied these rumors, and said that Jason Wu is in excellent physical condition and is devoting himself to the filming and post-production of the new film.

Jason Wu’s studio said in a statement that the rumors about Jason Wu’s hospitalization are completely false. Jason Wu is in good health and is making every effort to shoot and post-produce the new film. He said that it is precisely because of this professionalism and dedication that the audience can see one high-quality work after another.

Jason Wu fans are very pleased with the clarification of this rumor. They cheered for Jason Wu on social media and wished him success in his work and good health. Many fans also expressed their love and expectation for Jason Wu’s performance, expecting his new work to meet you as soon as possible.

As a public figure, Jason Wu is not only responsible for his body, but also for his fans. The clarification of this incident made everyone feel Jason Wu’s sense of responsibility and responsibility. Generally speaking, the rumor that Jason Wu is in hospital has been proved to be false. He is in good health and is devoting himself to the filming of the new film. We believe that he will continue to bring you more wonderful works, and hope that everyone can pray for his health.

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The Israeli government demanded that Gaza residents withdraw from South Pakistan, saying it would have disastrous consequences.

　　Xinhua News Agency, Beijing, October 13th Comprehensive Xinhua News Agency reporters reported that the Israeli military issued a statement on the 13th, saying that all residents in the northern part of the Gaza Strip were required to evacuate to the southern part for "humanitarian" reasons, which triggered strong criticism from Palestinians, regional countries and the League of Arab States. On the same day, Palestinian Prime Minister Ashtiyah warned Israel not to send ground troops to the Gaza, believing that this would lead to "disastrous consequences".

　　The Israeli military issued a video statement on the morning of 13th, demanding that all residents in the northern part of the Gaza Strip evacuate to the southern part, saying that the evacuation was required for "humanitarian" reasons and "to ensure the safety of residents in northern Gaza". The statement said that Hamas launched a war against Israel, and the Israeli army is carrying out military operations in the Gaza Strip, demanding that all residents in the northern part of the Gaza Strip be evacuated for security reasons.

　　In response, a number of Palestinian media quoted the Hamas Media Office as saying that this was "false propaganda" and "psychological warfare" by the Israeli side, and called on Palestinians not to be misled. The United Nations Relief and Works Agency for Palestine Refugees in the Near East said on social media that it had moved its institutions and staff to the southern part of the Gaza Strip.

　　The Arab League issued a statement on the 13th, condemning Israel’s demand for residents from the northern part of the Gaza to evacuate to the south, considering it a "new war crime" committed by Israel, and calling on the international community to unite and stop Israel’s actions. The statement said that Arab League Secretary-General Gheit had sent an urgent letter to UN Secretary-General Guterres, asking him to "stop Israel from committing new war crimes".

　　The Palestinian Ministry of Health said on the 12th that since the outbreak of the new round of Palestinian-Israeli conflict, Israel has killed 1,843 Palestinians and injured 6,638 others in the Gaza and the West Bank. The United Nations Relief and Works Agency for Palestine Refugees in the Near East issued a statement on the same day, saying that more than 340,000 people have been displaced in the Gaza since the escalation of the Palestinian-Israeli conflict.

　　The Kasang Brigade, an armed faction affiliated to Hamas, issued a statement on the 13th, saying that 13 hostages, including foreigners (non-Israelis), have been killed by Israeli air strikes in the Gaza in the past day. According to Palestinian media reports, at least seven people were killed in clashes between Palestine and Israel in various areas of the West Bank on the afternoon of the 13th.

　　Palestinian Prime Minister Ashtiyah made a televised speech on the 12th, warning Israel not to send ground troops to the Gaza, and "any ground invasion will bring disastrous consequences". He said that the top priority of the Palestinian leadership now is to stop the Israeli "aggression" against the Gaza Strip. He called on the international community to curb this "aggression" and said that the Palestinian leadership is cooperating with Egypt to open humanitarian corridors to provide assistance to the Gaza Strip.

　　King Abdullah II of Jordan, when meeting with visiting US Secretary of State Blinken in Amman on the 13th, stressed the need to open emergency humanitarian corridors to transport much-needed medical and relief supplies to the Gaza, and at the same time stressed the need to protect civilians and try to calm the current conflict. Abdullah II warned against any attempt to forcibly expel Palestinians from Palestinian territory or cause them to be displaced, and called for preventing the crisis from spreading to neighboring countries or worsening the refugee problem. He stressed the need to strengthen international efforts to stop the escalation of the situation in the Gaza Strip and prevent it from spreading to the West Bank.

　　On the 12th, Abdullah II met with visiting Palestinian President Abbas in Amman. The two sides believe that the humanitarian crisis in the Gaza Strip is deteriorating and call for an end to the escalation of the situation. The two sides urged the relevant parties to open the emergency humanitarian corridor, so as to deliver much-needed medical and relief materials to the Gaza Strip and ensure the local water and electricity supply.

　　Iranian Foreign Minister Abdullahiyan, who is visiting Lebanon, stressed on the 13th that Lebanon and Iran agree that it is necessary to immediately stop the war crimes committed by the occupiers against the defenceless Palestinian people. Abdullahiyan said that the invasion of Gaza would trigger a regional war. He called for a just and comprehensive solution for the Palestinian people.

　　Lebanese Prime Minister Mikati on the 12th called on the international community, including the UN Security Council, to urge a ceasefire and start negotiations. Mikati emphasized that the Arab Peace Initiative is the only road map to achieve peace and give Palestinians their legitimate rights. Lebanese Foreign Minister Habib called on the international community to put pressure on Israel to stop the war, calling for a just, permanent and comprehensive solution to the problem and peace through the establishment of an independent Palestinian state.

　　John Kirby, strategic communications coordinator of the National Security Council, said on the 12th that the United States has no intention or plan to send ground troops to Israel. He said that Israel has made it clear that foreign troops are not welcome to enter its territory under any circumstances.

　　Norwegian Foreign Minister Huitfeldt said on the 12th that the Israeli blockade of the Gaza Strip is unacceptable. It is Israel’s obligation to ensure that civilians in the Gaza receive humanitarian assistance. She also said that it is imperative that all parties to the conflict immediately stop violence and avoid any actions that may lead to further escalation of the situation. The only way to achieve lasting peace is to restart the political negotiation process between Israel and Palestine.

　　The Russian Foreign Ministry issued a statement on the 12th, saying that the Israeli air force’s attack on the runways of Damascus and Aleppo international airports in Syria that day was a serious violation of Syria’s sovereignty and the basic norms of international law. This military action may lead to extremely dangerous consequences and lead to an escalation of the situation in the whole region.

　　French President Macron said in a televised speech on the situation in Palestine and Israel on the evening of 12th that the Palestinian-Israeli conflict has killed 13 French nationals and left 17 others missing.

The incidence of colorectal cancer in Shanghai has increased more than five times in 50 years, which is related to the westernization of life and diet structure.

The high incidence of colorectal cancer is not only related to the improvement of life expectancy and medical diagnosis and treatment level in Shanghai, but also to the change of people’s lifestyle. Gao Jianping’s surging information

In the past 50 years, the incidence of colorectal cancer in Shanghai has increased more than five times, reaching 55-56/100,000 in 2013. There are as many as 8000 new cases of intestinal cancer in Shanghai’s permanent population every year.

Experts pointed out that in the past, the high incidence of colon cancer in Chinese was different from that in the west, and the common high incidence was rectal cancer and sigmoid colon cancer, but now the incidence of colon cancer has increased significantly. This is mainly related to the westernization of people’s life and diet structure.

On August 20th, reporter The Paper (www.thepaper.cn) learned from Shanghai International Medical Center that a multi-disciplinary (MDT) consultation platform across hospitals appeared in Shanghai, and the first disease that experts focused on was colorectal cancer, which was also the first comprehensive consultation platform project across multiple hospitals and disciplines in China.

Screening: 1.78 million retired people have a high risk of 340,000

Cai Sanjun, director of colorectal surgery at Fudan University Cancer Hospital and chief expert of multidisciplinary treatment group for colorectal cancer, revealed that epidemiological investigation found that the incidence of colorectal cancer in Shanghai increased more than five times in the past 50 years, from 87/100,000 in 1962 to 55-56/100,000 in 2013. Since 2003, colorectal cancer has jumped to the second place in the incidence of malignant tumors.

"At present, there are 8,000 new cases of colorectal cancer in Shanghai’s permanent population every year, and the incidence of colorectal cancer will rise in the future." Cai Sanjun said that the high incidence of colorectal cancer is not only related to the improvement of life expectancy and the level of medical diagnosis and treatment in Shanghainese, but also an important reason is the change of people’s lifestyle.

Zhang Jun, deputy director of the oncology department of Ruijin Hospital, also agreed. He revealed that in the past, the high incidence of colon cancer in Chinese was different from that in the west, and the common high incidence was rectal cancer and sigmoid colon cancer, but now the incidence of colon cancer has increased significantly. This is mainly related to the westernization of people’s life and diet structure.

An epidemiological report on cancer in Shanghai shows that the incidence of colon cancer has surpassed that of rectal cancer since 1991, and the gap is gradually widening. In 2011, the incidence of colon cancer accounted for 59.6% of colorectal cancer. The data shows that there are more than 10,000 patients with intestinal cancer in Shanghai municipal hospitals every year, including 3,000-4,000 patients from other places. It is estimated that the annual operation volume of intestinal cancer in Shanghai, including secondary hospitals, is between 12,000 and 13,000. "

According to Cai Sanjun, a project of "colorectal cancer screening for community residents" is being carried out in Shanghai, covering the permanent population who have reached retirement age and participated in various basic medical insurance and basic medical security in Shanghai. The plan is to complete the screening of 4 million people, but only 1.78 million people have been completed so far, mainly because the awareness of community residents’ participation is not strong. However, among the 1.78 million retired people who have been screened, there are 340,000 high-risk groups.

"It is reasonable that these 340,000 people should go for further examination of colonoscopy, but only 94,000 people have done it." Cai Sanjun said that among 94,000 people, 2,100 were diagnosed with intestinal cancer, 40% of them were still in the early stage, and after treatment, the 5-year survival rate could reach over 95%, while 18,000 people were found to have colorectal polyps, 60% to 70% of which may become cancerous when they grow up.

"I can imagine how many patients with early intestinal cancer will not be found in time in the rest of the population." Cai Sanjun appealed to the public to actively participate in and cooperate with this screening work.

Consultation platform: more than 30 top three experts participated.

Previously, the treatment of colorectal cancer was mainly focused on surgery, and no other disciplines were involved.

After 1990s, radiotherapy and chemotherapy proved their value in colorectal cancer. Liver metastasis and lung metastasis of colorectal cancer need the active participation of liver surgery and lung surgery. At the same time, in the field of medical diagnosis, imaging, endoscopy and other disciplines can provide the location, size and staging of tumors more accurately. This makes the determination of the correct diagnosis and treatment plan for colorectal cancer involve more and more departments. It is also on this basis that multidisciplinary diagnosis and treatment came into being.

However, in the multidisciplinary diagnosis and treatment carried out by traditional medical institutions, patients with incurable diseases often have to move from department to department, waiting in line repeatedly, and being exhausted. Complex diseases often merge with other problems, and doctors in each department can only give patients advice from their own fields. "Various departments are often’ railway police, each in charge of a section’ and’ treating the headache and treating the foot pain’, and the final treatment effect of patients is often greatly reduced." Zhang Wei, director of anorectal surgery at Changhai Hospital, said.

With the launch of the Multidisciplinary (MDT) consultation platform of Shanghai International Medical Center, it is a reality for patients with difficult colorectal cancer to get comprehensive consultation from experts in major hospitals in one stop.

"After the establishment of a cross-hospital multidisciplinary diagnosis and treatment platform, it is no longer the patients who are transferred between hospitals and departments, but our doctors. Therefore, on this diagnosis and treatment platform, everything starts from the diagnosis and treatment of patients and diseases." Yu Zhiqing, Dean of Shanghai International Medical Center, said that at present, this project platform has attracted more than 30 industry experts from Shanghai Cancer Hospital, Changhai Hospital, Ruijin Hospital, Renji Hospital and Longhua Hospital.

"These medical experts are well-known experts in the field of colorectal cancer diagnosis and treatment, and everyone is highly specialized in their own fields. Experts participate in this comprehensive consultation platform. On the one hand, they hope to work out the optimal treatment plan for patients with intractable diseases through cross-hospital cooperation. On the other hand, I also hope that in the interdisciplinary collision, experts can reach a better understanding and development. " Yu Zhiqing said.

According to the Shanghai International Medical Center, the MDT team of colorectal cancer in the medical center will give free consultation to 20 patients on August 21st, and select 5 difficult cases from them, and invite experts from all over the city for joint consultation. The first joint consultation of experts in the city is a public welfare project, with a quota of 5 people and no registration fee.

Zhang Jun said that at present, the UK law mandates that cancer diseases must be discussed through multiple disciplines. Comparative data abroad show that multidisciplinary diagnosis and treatment has obvious advantages compared with traditional diagnosis and treatment. "However, due to the large number of patients in China, it is unrealistic for all patients to undergo multidisciplinary comprehensive diagnosis and treatment. Therefore, at this stage, multidisciplinary comprehensive diagnosis and treatment is mainly for patients with incurable diseases and willing patients. At the same time, in order to ensure the actual effect of multidisciplinary comprehensive diagnosis and treatment, the number of patients open every week should not be too much. "

The harvest of autumn crops in Henan exceeded 114 million mu, and the grain production structure was optimized to increase production and income.

CCTV News:As of October 18th, autumn crops in Henan Province have harvested 114.77 million mu, accounting for 96.4% of the planting area. Except for some late crops such as rice and sweet potato along the Yellow River, the autumn harvest in Henan Province has basically ended.

Autumn crops in Henan Province mainly include corn, rice, soybeans and other food crops and oil crops such as peanuts and sesame seeds. Relevant departments guide farmers to choose excellent varieties, vigorously promote technologies such as simultaneous sowing of corn seeds and fertilizers and mechanized transplanting of rice, and improve sowing quality.

This year is the first year of soybean and corn strip compound planting in Henan province. While stabilizing autumn grain production, Henan has adjusted its grain production structure to increase production and income.

Recently, pieces of vegetables in Suixian County, Henan Province have been harvested one after another. In the vegetable planting base, the green "Shanghai Green" crop is mature, and the villagers are busy collecting, packing and loading. The large-scale and facility development of vegetable planting industry has effectively improved the land utilization rate, and the local "Shanghai Green" planting has realized "planting in turn in four seasons and harvesting eight crops a year". At present, the vegetable planting in Sui County is stable at more than 260,000 mu, and the total output is stable at about 750,000 tons.

The General Office of the Ministry of Transport issued the ＂Guide to Transport Safety Services for Self-driving Cars (Trial)＂

Cctv news: The General Office of the Ministry of Transport issued the Guide to Transport Safety Services for Self-driving Vehicles (Trial). It is clear that the use of self-driving cars to engage in urban bus and tram passenger transport, taxi passenger transport, road passenger transport and road cargo transport should adhere to the principles of compliance with laws and regulations, honesty and trustworthiness, safety first and innovation drive. The transportation management of self-driving cars should adhere to the principles of safety first, integrity and innovation, inclusiveness and openness, and orderly advancement.

Self-driving car transport safety service guide (Trial)

In order to guide the development of autonomous driving technology and standardize the application of autonomous vehicles in the field of transportation services, this guide is formulated in accordance with the laws and regulations such as the Law of People’s Republic of China (PRC) on Safety in Production, the Law of the People’s Republic of China on Road Traffic Safety, the Regulations of the People’s Republic of China on Road Transportation, and the relevant provisions on road transportation and urban passenger transport management.

I. Scope of application

These Guidelines shall apply to those who use self-driving cars to engage in urban bus and tram passenger transport, taxi passenger transport, road passenger transport and road cargo transport business activities on urban roads, highways and other roads used for social motor vehicles.

The self-driving cars mentioned in this guide refer to cars that have the ability to perform all dynamic driving tasks under the design and operation conditions according to the relevant national standards and are included in the product access scope by the industrial and information departments, including conditional self-driving cars, highly self-driving cars and fully self-driving cars specified in the national standard "Classification of Automobile Driving Automation" (GB/T40429-2021).

Second, the basic principles

Using self-driving cars to engage in urban bus and tram passenger transport, taxi passenger transport, road passenger transport and road cargo transport (hereinafter referred to as self-driving transport) should adhere to the principles of compliance with laws and regulations, honesty and trustworthiness, safety first and innovation drive. The transportation management of self-driving cars should adhere to the principles of safety first, integrity and innovation, inclusiveness and openness, and orderly advancement.

Third, the application scenario

In order to ensure transportation safety, self-driving cars should carry out road transportation services in designated areas and pass the road traffic safety assessment according to law. Using self-driving cars to engage in urban bus and tram passenger transport business activities can be carried out in a physically closed, relatively closed or simple fixed line and traffic safety controllable scene; Using self-driving cars to engage in taxi passenger transport business activities can be carried out in the scene of good traffic conditions and controllable traffic safety; Prudent use of self-driving cars to engage in road passenger transport business activities; Self-driving cars can be used to engage in road cargo transportation business activities in scenes such as point-to-point trunk road transportation or urban roads with controllable traffic safety; It is forbidden to use self-driving cars to engage in road dangerous goods transportation business activities.

Four, automatic driving transport operators

Operators who use self-driving cars to engage in urban bus and tram passenger transport, taxi passenger transport, road passenger transport and road cargo transport (hereinafter referred to as self-driving transport operators) shall register market entities according to law, and their business scope shall register corresponding business categories; Taxi passenger transport (network car) and road passenger transport should be insured with carrier liability insurance according to law. Those who engage in the operation of urban public buses and trams shall meet the relevant operational requirements of the state and the people’s government of the city where they operate. Engaged in taxi passenger transport, road passenger transport business, road cargo transport business, should have the business license qualification of the corresponding business category. Urban passenger transport enterprises and road transport enterprises can form a consortium with automobile production enterprises to carry out self-driving transport operations. Self-driving transport operators shall go through the relevant formalities according to law, and local transportation authorities shall provide handling channels for self-driving transport operators to engage in self-driving automobile transport business services.

V. Transport vehicles

Self-driving cars engaged in road transport business should meet the requirements of relevant national standards and technical specifications, register motor vehicles according to law, and obtain motor vehicle number plates and motor vehicle driving licenses. Self-driving cars engaged in urban bus and tram passenger transport should meet the relevant operational requirements of the state and the people’s government of the city where they operate. Self-driving cars engaged in taxi passenger transport, road passenger transport and road cargo transport should also meet the requirements of the technical standards for the safety of operating motor vehicles in the transportation industry, and obtain the Network Appointment Taxi Transport Certificate or Road Transport Certificate issued by the transportation authorities at the place of operation according to law. If the self-driving car needs to change the automatic driving function and upgrade the vehicle software system, it should be implemented in accordance with the regulations of the industrial and information departments to ensure the safe operation of the vehicle.

Self-driving cars engaged in road transport business shall provide traffic accident liability compulsory insurance certificate, traffic accident liability insurance certificate or accident compensation guarantee in accordance with the relevant requirements of Road Traffic Safety Law of the People’s Republic of China, Regulations of the People’s Republic of China on Road Transport, Regulations on Compulsory Insurance of Motor Vehicle Traffic Accident Liability and Notice of the Ministry of Industry and Information Technology and the Ministry of Public Security on Printing and Distributing the Management Specification for Road Testing and Demonstration Application of Intelligent Networked Vehicles (Trial) (No.97 [2021] of the Ministry of Industry and Information Technology).

VI. Staffing

Self-driving cars engaged in urban bus and tram passenger transport and road passenger transport should be equipped with a driver or operation safety guarantee personnel (hereinafter referred to as "safety officers"). Self-driving cars engaged in road freight transportation are equipped with safety officers on board in principle. Conditional self-driving cars and highly self-driving cars engaged in taxi passenger transport should be equipped with a safety officer; Fully self-driving cars engaged in taxi passenger transport can use remote safety officers when operating in designated areas with the consent of the people’s governments of districts and cities under the premise of ensuring safety, and the ratio of remote safety officers to vehicles shall not be less than 1:3. Safety officers shall receive training in self-driving car technology and related transportation business, be familiar with the provisions of road traffic safety laws and regulations, the operation skills of different levels of self-driving systems, be familiar with the running routes of self-driving cars, and have the ability to take over vehicles in an emergency. After the automatic driving function of self-driving cars is changed or updated and upgraded, the self-driving transport operators should strengthen the on-the-job training of safety officers in time to ensure that they can master new functions, new technologies and new requirements in time. Safety personnel shall comply with the relevant regulations and requirements for the management of employees in the field of transportation and obtain the qualifications of corresponding business categories.

VII. Safety and security

(1) Safety production system.

Self-driving transport operators should fulfill the main responsibility of production safety, and establish and implement operational safety management systems, including but not limited to the responsibility system for all employees’ production safety, vehicle technical management system, safety evaluation system, safety hidden danger investigation and management system, dynamic monitoring management system, network safety management system, employee safety management system, key post safety operation procedures, safety production and emergency response education and training plan, etc.

(2) Transportation security.

Self-driving transport operators should establish and improve the transport safety guarantee system. Before the formal operation, they should formulate the transport safety guarantee scheme for self-driving vehicles, and clarify the design and operation conditions, staffing, operational safety risk list, grading control measures and emergency response measures of self-driving vehicles. Self-driving transport operators should sign agreements with automobile production enterprises and safety officers, clarify the rights, responsibilities and obligations of all parties, and organize professional demonstration and safety risk assessment of transport safety guarantee schemes. The transportation safety guarantee scheme and safety risk assessment report shall be informed to the transportation authorities, public security traffic police departments and emergency management departments at the place of operation. Self-driving transport operators should ensure transport safety; If there are major hidden dangers that cannot guarantee transportation safety, the automatic driving transportation operation should be suspended in time according to law.

(3) Operation status information management.

Self-driving transport operators should ensure that the vehicle is in good technical condition and operate according to the vehicle instruction manual. Self-driving cars engaged in road transport business should have the functions of recording, storing and transmitting vehicle running state information, and transmit key running state information to the self-driving transport operators and relevant competent departments in the operation area in real time. When an accident happens to a vehicle or the automatic driving function fails, the running state information of at least 90 seconds before the accident should be automatically recorded and stored. The running status information includes but is not limited to the following 10 items: vehicle identification (frame number or vehicle number plate information, etc.); Vehicle control mode; Vehicle position; Motion states such as vehicle speed, acceleration and driving direction; Environmental perception and response state; Real-time status of vehicle lights and signals; 360-degree video monitoring outside the vehicle; In-vehicle video and voice monitoring that reflects the state of human-computer interaction between the driver and the vehicle; Remote control instructions received by the vehicle (if any) and vehicle fault conditions (if any).

(4) Vehicle dynamic monitoring.

If the vehicle conforms to the Measures for the Dynamic Supervision and Management of Road Transport Vehicles and the relevant provisions of the state, it is necessary to strengthen the dynamic monitoring of self-driving vehicles, monitor and manage the vehicle operation area, operation line and operation status, and promptly remind and correct and deal with illegal acts. The transportation authorities at the place of operation should urge the self-driving transport operators to strengthen the dynamic management of transport vehicles and safety personnel.

(5) Safety notification.

Self-driving cars should be marked with eye-catching patterns, words or colors on the body to clearly inform other traffic participants of their self-driving status. Operators who use self-driving cars to engage in urban bus and tram passenger transport, taxi passenger transport and road passenger transport should inform passengers of the automatic driving function, safe riding knowledge, the use of safety facilities, emergency escape methods and other matters by playing videos or posting signs.

(6) Emergency handling.

Self-driving transport operators should formulate emergency plans for the operation of self-driving cars, clarify the types and levels of emergencies, disposal methods, emergency response procedures, division of responsibilities and safeguard measures, and organize regular emergency drills. In case of vehicle failure or safety accident during the operation of self-driving cars, self-driving transport operators should start emergency response according to the requirements of emergency plan and make emergency treatment; In case of casualties in production safety accidents, it should be reported to the competent department of transportation in time in accordance with the relevant provisions of the state.

Eight, supervision and management

(1) Daily supervision.

The competent department of transportation shall, jointly with relevant departments, strengthen the supervision and management of self-driving automobile transportation business activities, carry out supervision and inspection in accordance with the requirements of "double randomness and openness", and set their functions and powers according to law to urge self-driving automobile production enterprises and self-driving transportation operators to carry out road transportation business activities in strict accordance with relevant national laws and regulations to ensure transportation safety. Local transportation authorities may formulate safety requirements and measures higher than these guidelines in light of local conditions.

(2) rectification of hidden dangers.

If there are major safety hazards in using self-driving cars to engage in road transport business activities, the transportation authorities at the place of operation shall, jointly with relevant departments, determine their functions and powers according to law and order self-driving car manufacturers and self-driving transport operators to make rapid rectification. If transportation safety cannot be guaranteed, it shall be dealt with according to laws and regulations such as the Law of People’s Republic of China (PRC) on Safety in Production, the Law of the People’s Republic of China on Road Traffic Safety and the Regulations of the People’s Republic of China on Road Transportation.

(3) Information feedback.

If there are technical defects, hidden dangers and problems in the operation of self-driving cars, the self-driving transport operators should give feedback to the relevant competent departments in accordance with the law, and the relevant competent departments should urge the automobile production enterprises to quickly investigate and rectify, eliminate potential safety hazards in time and ensure production safety. The transportation authorities in the place of operation should regularly monitor and summarize the local autonomous driving operation services and master the industry safety and operation services. Provincial transportation authorities should report to the Ministry before the end of each year on the operation of self-driving automobile transportation within their respective jurisdictions.

The flowing China is full of energy! In 2025, Spring Festival travel rush needs to know this information.

CCTV News:There is still half a month before New Year’s Eve. Have you got a ticket to go home? On January 14th, 2025, Spring Festival travel rush will be opened. According to the forecast of the Ministry of Transport, in the 40 days from January 14th to February 22nd, the cross-regional mobility of the whole society will reach 9 billion person-times. What information do you need to know about Spring Festival travel rush? What new service guarantee measures are there in various places? Let’s get to know each other

New Year’s Eve train tickets are on sale on the 14th.

Let’s look at railways first. In Spring Festival travel rush this year, the number of passengers sent by railways nationwide is expected to exceed 510 million, with an average of 12.75 million passengers per day, an increase of 5.5% compared with Spring Festival travel rush last year. Friends who are going home on New Year’s Eve should pay attention to the fact that train tickets for New Year’s Eve will be sold on the 14th.

The reporter learned from the Railway 12306 Science and Technology Innovation Center that since Spring Festival travel rush tickets were sold on December 31, 2024, by 16: 00 on the 13th, a total of 90.69 million tickets had been sold during Spring Festival travel rush. In addition, according to the data of 12306 pre-sale tickets and alternate ticket purchases, the railway department will increase the delivery of transportation resources in hot directions and time periods where conditions permit.

The first starting train in Spring Festival travel rush, Beijing, started in the early morning of the 14th.

In the early morning of January 14th, the first Spring Festival travel rush train was launched in Beijing.

The K4159 train from Beijing West to Hefei is the first Spring Festival travel rush train in Beijing this year. The ordinary speed train K4159 carries nearly 500 passengers and will arrive in Hefei in 12 hours.

In Spring Festival travel rush this year, the Beijing Bureau of China Railway covering Beijing, Tianjin and Hebei is expected to send 39.37 million passengers. In order to facilitate passengers’ travel, all stations provide night waiting service to ensure that passengers arriving in bad weather and at night and early morning have comfortable waiting conditions. More than 100 convenience lockers have been set up at the entrance security instruments of 22 stations, such as Beijing Railway Station and Beijing West Railway Station, to facilitate passengers to mail items that do not meet the requirements for taking the train quickly.

In addition, for passengers who take the Beijing-Hong Kong high-speed train and move to sleep, the ticket window, waiting room and platform will be strengthened, and passengers going to Hong Kong West Kowloon will bring valid entry and exit documents.

During Spring Festival travel rush, the railway department will increase the capacity in time according to the passenger flow. 220 pairs of passenger trains will be added during the peak period of passenger travel, mainly in Beijing to Harbin, Shenyang, Changchun, Taiyuan, Datong, Hohhot, Qingdao, Shijiazhuang, Baoding and Zhangjiakou. According to the pre-sale of tickets, the capacity will be supplemented by steps.

Lanzhou Bureau of China Railway expects Spring Festival travel rush to send passengers to break 10 million for the first time.

Lanzhou Bureau of China Railway expects to send 10.4 million passengers during Spring Festival travel rush this year, an increase of 5.1% compared with 2024, with an average of 260,000 passengers per day. This is the first time that Spring Festival travel rush, Lanzhou Bureau of China Railway, expects to send more than 10 million passengers.

In order to better ensure the work in Spring Festival travel rush, the station has launched special services such as "emergency help" and "waiting for mother and baby".

During the Spring Festival travel rush in 2025, the passenger flow within the jurisdiction of the Lanzhou Bureau of the State Railway was mainly based on college students returning home and returning passengers from Jiangsu, Zhejiang, Guangdong, Fujian, Sichuan and Chongqing before the festival; After the holiday, college students return to school and migrant workers from Beijing, Shanghai, Guangzhou and Urumqi are the main ones. In order to ensure the smooth flow of Spring Festival travel rush, 17 pairs of temporary passenger trains will be added to the railway, including 8 pairs of general-speed temporary passenger trains and 9 pairs of EMU temporary passenger trains.

During the period of Spring Festival travel rush, the average daily traffic of expressways was about 38.5 million vehicles.

On the highway side, on the 13th, the Road Network Monitoring and Emergency Disposal Center of the Ministry of Transport released the Judgment on the Operation of National Highway Network in Spring Festival travel rush in 2025. It is estimated that during the period of Spring Festival travel rush, the average daily traffic of expressways in China will be about 38.5 million, which is about 0.5% higher than that of Spring Festival travel rush in 2024. The peak traffic in Spring Festival travel rush is expected to appear on the penultimate day of the Spring Festival holiday, that is, the sixth day of the first month on February 3rd.

During Spring Festival travel rush, self-driving of passenger cars became the mainstream.

During the period of Spring Festival travel rush, there were many family trips back home, and self-driving of passenger cars became the mainstream, accounting for more than 98% of passenger cars, among which new energy vehicles continued to grow. It is estimated that the traffic volume of new energy vehicles will account for about 19% of the total traffic volume during Spring Festival travel rush, which is a significant increase compared with the same period in 2024.

In addition, during the period of Spring Festival travel rush, the flow of people showed tidal characteristics. Before the holiday, megacities and provincial capitals mainly migrated to neighboring cities and major labor exporting provinces and cities, and after the holiday, the flow was reversed.

The national road network operation changes are divided into three stages: the band fluctuates in the early and late stages, and it is low before and then high during the Spring Festival.

The Research on the Operation of National Highway Network in Spring Festival travel rush in 2025 points out that during the period of Spring Festival travel rush, the operation change of national highway network is divided into three stages, which generally presents the characteristics of "band fluctuation in the early and late stages, low before and high after the Spring Festival".

The first stage, from January 14th to January 27th, is the early stage of Spring Festival travel rush. Before January 23rd (the 24th of the twelfth lunar month), the traffic on the road network was mainly composed of student flow, work flow and freight flow. On January 19th, around the 20th of the twelfth lunar month, the first wave of small peaks of returning home appeared. On January 26th, around the 27th of the twelfth lunar month, there was a second wave of small peak of returning home. After that, the return flow of enterprises and institutions increased, the proportion of trucks decreased day by day, and the inter-provincial traffic decreased compared with the previous stage.

The second stage is the Spring Festival holiday. From January 28th to February 4th, the traffic volume of the road network reached a holiday low point on New Year’s Eve and the first day of the first month. On January 30th, the traffic volume of the road network gradually picked up from the second day of the first month, and on February 3rd, the sixth day of the first month, the traffic volume returned to Spring Festival travel rush.

The third stage is the late Spring Festival travel rush, from February 5 to February 22. On February 5, from the eighth day of the first month, the traffic quickly fell back to the daily level. On February 13th, the second peak of return traffic appeared around the 16th day of the first month, and then ended in Spring Festival travel rush, where the traffic changed slowly and gradually returned to normal.

Tianjin: Spring Festival travel rush on the water is busy expecting more than 9,000 sub-ships to enter and leave the port.

The reporter learned from the Tianjin Maritime Department that during the Spring Festival travel rush this year, the water traffic flow in Tianjin’s jurisdiction will reach a peak. It is estimated that there will be more than 9,000 ships entering and leaving Tianjin Port, with a cargo throughput of about 48 million tons and a container throughput of about 2.1 million TEUs. The total number of passengers transported by international cruise ships, Haihe ferry boats and tourist boats is expected to reach 87,000. To this end, the Tianjin Maritime Department has coordinated 156 ships and 4 aircraft in the jurisdiction to maintain an emergency state to ensure a safe and orderly water traffic environment.