In the face of the ＂cliff-like＂ decline in the price of centralized mining, how to deal with the heart stent enterprises？

Sheng: the "past lives" of heart stent

Cardiac stent, also known as coronary stent, is a high-value consumable commonly used in percutaneous coronary intervention (PCI), which has the function of dredging arterial blood vessels and is recognized as a conventional treatment for cardiovascular diseases. Since the first generation of stents went on the market in 1997, the development of cardiac stents has gone through three stages, the first generation is the balloon expansion era, the second generation is the bare metal stent era, the third era is the drug-eluting stent era, and it is now moving towards the fourth generation of completely degradable stents. With the continuous evolution of materials, the performance is more and more optimized. The main features of each generation of cardiac stents are as follows:

Fig. 1 development of cardiac stent

At present, non-degradable drug eluting stent,DES) is still the mainstream choice for clinical application, and fully degradable stent is still in the early stage of product development and clinical application. At present, the mainstream cardiac stents in the market are still drug-eluting stents, and the market share has remained at around 99% since 2012, and balloons and bare metal stents have been completely replaced by them. Biodegradable stents (BRS) can be gradually absorbed in the body, which can significantly reduce the formation of stent thrombosis and restenosis, at the same time, it will not affect MRI and CT scanning, and also facilitate the re-intervention process. It is the main direction of stent research and development in the world, and has attracted extensive attention from medical device companies at home and abroad. At present, the fully degradable heart stents put into research and development are mainly divided into two categories: degradable metal materials and degradable polymer materials.

Fig. 2 Types of mainstream cardiac stents currently in use

(A) In recent years, the demand for cardiac stents has been increasing, and the scale has steadily increased.

1. The number of PCI interventions in China ranks first in the world, and the number of PCI interventions has increased by over 15% annually in recent five years.

From 2015 to 2019, the number of cases of percutaneous coronary intervention (PCI) in China increased steadily, with an average annual increase of 16.0%. Among them, the number of percutaneous coronary intervention (PCI) in China in 2019 was 1.03 million, ranking first in the world, with an increase of 12.6% compared with 2018. It is conservatively estimated that there will be nearly 1.2 million cases of percutaneous coronary intervention (PCI) in China in 2020.

Fig. 3 Trends of PCI operation volume in China from 2015 to 2020 (data source: analysis by Health Research Institute).

In 2020, the market value of heart stents in China is close to 17.5 billion yuan.

From 2015 to 2019, the number of cardiac stents implanted in China showed a steady growth trend year by year, with an annual growth rate of 15%-20%. In 2019, the number of cardiac stents implanted in China was 1.6 million. In terms of market value, the market value of heart stents in China increased from 9.75 billion yuan to 15.97 billion yuan from 2015 to 2019, with an average annual growth rate of 15.2%. It is estimated that the market value will be close to 17.5 billion yuan in 2020.

Fig. 4 Trend chart of cardiac stent implantation quantity and scale in China from 2015 to 2020 (data source: analysis by Health Research Institute).

(B) The "market just needs+policy orientation+technology promotion" troika escorts the rapid development of the cardiac stent industry.

1. The market just needs:The two major trends of younger coronary heart disease and aging population have once again "expanded" the cardiac stent market.

Younger coronary heart disease:Cardiovascular disease has become the number one health killer in the world, accounting for nearly 30% of the total global deaths. According to China Cardiovascular Health and Disease Report 2019, the number of cardiovascular patients in China reached 330 million, accounting for more than 45% of the deaths of residents, ranking first among all diseases. Among them, the number of patients with coronary heart disease has reached 11 million, with more than 3 million new patients each year and more than 1 million patients with sudden infarction. In addition, the younger trend of coronary heart disease (CHD) is increasing. According to a survey of cardiovascular diseases among more than 20,000 people in Shanghai, the number of patients with CHD accounts for nearly 30%, of which 27.0% are over 70 years old, 40.0% are 51-70 years old, and 33.0% are under 50 years old. CHD is no longer a "patent" for the elderly, and it is obese, stressful and stressful.

Figure 5 Proportion of cardiovascular disease population structure (data source: public information)

Aging:According to statistics, in 2019, the population aged 65 and above accounted for 12.6% in China. From the development trend, the population aging speed and scale in China are unprecedented. After 2022, China will enter a deeply aging society with a proportion of over 14.0%, a super aging society with a proportion of over 20.0% around 2033, and then it will continue to rise to 35.0% in 2060. The arrival of the era of deep aging will undoubtedly raise the "ceiling" of the heart stent industry.

Figure 6 Structural trend of population aging in China (data source: public information)

With the development of younger coronary heart disease and aging population, and considering the impact of centralized procurement on the price of cardiac stents and the improvement of people’s health awareness, the number of PCI operations per capita in China will be in line with that of developed countries in the future (the number of PCI operations per million population in China is 736, that in the United States is about 3,135, and that in Japan is about 2,047, which is 4.3 times and 2.8 times that in China, respectively). According to the extreme analogy method (referring to the number of PCI operations per million people in Japan, mainly considering that China and Japan are similar in race and incidence), it is estimated that the peak number of PCI operations will reach 2.87 million in the future. Considering the average number of stents implanted in PCI (about 1.5 stents/case), the corresponding peak number of cardiac stents implanted is about 4.3 million, which has a large long-term permeability and market space.

Fig. 7 Comparison of the number of percutaneous coronary intervention (PCI) between China and major developed countries (data source: analysis by Health Research Institute).

2. Policy orientation:Front-end encouraging innovation and end-collection specification help the market demand of cardiac stents to be released continuously.

In recent years, the state has launched a series of favorable policies for the medical device industry to support the rapid development of enterprises:

innovateEncourage the acceleration of the transformation and upgrading of medical devices, develop high-end interventional products such as fully degradable vascular stents, and stimulate the development of new cardiac stents market segments; Priority is given to the review and approval of qualified innovative medical devices. Under the promotion of innovation policy, the fully degradable polymer matrix drug (rapamycin) eluting stent system (NeoVas) independently developed by Lepu Medical and the fully degradable polylactic acid stent (Xinsorb) independently developed by Academician Ge Junbo of China Academy of Sciences have all entered the special approval procedures for innovative medical devices.

circulateFrom the national level to the provinces and cities, the centralized purchasing scheme of high-value consumables has been launched one after another, constantly rationalizing the price system of high-value medical consumables and improving the supervision and management of the whole process. In October 2020, coronary stents became the first batch of purchased varieties, and the national level started the collection of high-value medical consumables.

Table 1: Main policies related to high-value consumables such as cardiac stents from 2016 to present:

3. Technology promotion:The iterative upgrading of products and the improvement of interventional surgery level greatly enhance patients’ confidence and willingness to receive interventional therapy.

Iterative upgrade of products: cardiac stent has experienced the development from balloon expansion to drug-eluting stent, and the restenosis rate of stent implantation has decreased by nearly 20%, and the incidence of thrombosis in stent has decreased to about 1%, which effectively reduces the risk of complications for patients;

Improving the level of interventional surgery: China has successively established the training base of cardiovascular interventional diagnosis and treatment of the Ministry of Health and the national quality control center of PCI, and adopted a unified training model to carry out systematic training nationwide, and issued certificates after passing the examination, and carried out quality control and index monitoring on related work. In 2018, the mortality rate of interventional therapy for patients with coronary heart disease was 0.26%, far lower than that in the United States.

(III) Competition pattern: Domestic substitution in the cardiac stent industry has basically been completed.

After decades of development, the technical generation gap among major enterprises has gradually narrowed, and the industry pattern has been basically stable, mainly relying on the launch of new products to enhance market share. Judging from the competition pattern, the concentration of cardiac stent industry is high, and the market share of domestic drug stent products exceeds 70%, and the domestic substitution is basically completed. Among them, domestic brands such as Weichuang, Lepu and Jiwei rank among the top three, with a total market share of over 65%.

Figure 8 Market share of domestic cardiac stent brands in 2019 (data source: analysis by Health Research Institute)

In 2019, the revenues of cardiac stents (including balloons, catheters and other ancillary products) of minimally invasive medical care, Lepu medical care and Jiwei medical care were 1.83 billion yuan, 1.79 billion yuan and 1.74 billion yuan respectively, with growth rates of 33.0%, 26.7% and 24.9% respectively. As can be seen from the figure, cardiac stents of minimally invasive medical care showed a trend of "double high" in sales growth rate and market share.

Figure 9 Market share and revenue growth rate of cardiac stent head enterprises (data source: analysis by Health Research Institute)

Change: the national "group purchase" triggered a major change in the heart stent industry.

With the landing of the national heart stent collection, the "suicide" price reduction of enterprises has also brought infinite reverie to the future direction of the industry. Will the heart stent industry under centralized procurement be a "broken wrist" or a "rescue" in the future? Is it "price for quantity" or "innovation and transformation"?

(A) the change in scale

Centralized procurement of cardiac stents directly affects the purchase price. According to the recent centralized purchasing list published by the Medical Insurance Bureau, the number of intentional purchases in the first year exceeded 1.07 million, involving 27 products. Based on the published average price quoted by the winning bidder (1682 yuan/piece) and the amount of coronary stents implanted in 2021, the market value in 2021 is about 3.19 billion yuan. It should be emphasized that the market value forecast here does not consider the impact of the decline in centralized purchasing price on the improvement of patients’ willingness to operate.

Fig. 10 Market value forecast of cardiac stent in 2021 (data source: analysis by Health Research Institute)

According to the previous estimation of the amount of cardiac stent implantation in China, when the amount of PCI operation per 100 people reaches the Japanese level, the peak amount of cardiac stent implantation in China is 1400 x 2047 x 1.5 = 4.3 million. According to the heart stent of 1682 yuan/piece (the average price of centralized procurement), the corresponding market value of heart stent is 7.23 billion yuan:

Fig. 11 Market value of China cardiac stent corresponding to peak value (data source: analysis by Health Research Institute)

From the above analysis, it can be seen that under the influence of centralized procurement policy, the market value of heart stents in China in the next 1-3 years is expected to be in the range of 3-7 billion yuan.

How much money can patients save after centralized collection?

As we all know, the "floor price" of centralized purchasing has a great influence on patients who are unwilling to undergo interventional surgery because of the high price. This paper analyzes the payment situation of patients before and after centralized purchasing (according to the conventional reimbursement policy):

Fig. 12 Comparison of patients’ self-funded amount before and after centralized purchasing (data source: analysis by Health Research Institute)

As can be seen from the above figure, according to the same reimbursement policy, the out-of-pocket medical expenses of patients decreased from 6520 yuan to 308 yuan before and after centralized purchasing, and the personal burden was only 4.7% of the original, which greatly eased the economic burden.

(2) Changes in business

In addition to the industry scale being affected, the business tentacles of heart stent enterprises will also be adjusted:

1. Stent market: form a low-cost medical insurance centralized procurement market+off-standard non-medical insurance high-end alloy stents+medical insurance stainless steel stents+non-medical insurance ultra-high-end degradable stents.

In the short term, the market of cardiac stent products will form a pattern of low-cost medical insurance centralized procurement market+off-standard non-medical insurance high-end alloy stent+medical insurance stainless steel stent+non-medical insurance ultra-high-end degradable stent:

On the one hand, from the current attitude of centralized mining, bare metal stents are not included in the list of centralized mining, and the price of stainless steel stents will be under pressure due to the price reduction of centralized mining in the short term, and the price inversion with alloy stents will not last long; In the long run, stainless steel stents are not as good as alloy stents in terms of support and passability. As a more backward technology than Co-Cr alloy and Pt-Cr alloy, stainless steel stents will face marginalization in the future. However, in view of the fact that the use of stainless steel coronary stents still accounts for about 40% of the market share in 2019, stainless steel coronary stents will be coasting for a period of time in the future.

On the other hand, with the continuous promotion of cardiac stent collection, the trend of differentiation and stratification of end patients will become more obvious, and the group of self-paid high-priced stents may expand. Degradable stents and metal stents belong to two price bands, so it is impossible to talk about the market share substitution after the huge change of centralized purchasing price. Moreover, the proportion of consumables in the cost of PCI surgery has further decreased, and the audience’s marginal willingness to pay for innovative products is likely to increase. In the medium term, the development rhythm of fully degradable stents will continue to be stable, in order to get as much clinical data as possible, enhance the recognition and acceptance of products by more experts, doctors and patients, and enhance the high-end market share.

Figure 13 Future product layout of cardiac stent

2. Business reshaping: cultivate and expand new medical formats around the cardiovascular field, and make a forward-looking and diversified layout.

On the one hand, it conforms to the latest concept of "intervention without implantation" of the current interventional instruments, and extends upstream and downstream around the coronary intervention chain:

Product chain: the price reduction of metal stents will be the norm in the future, and the fully degradable stents and drug balloons with "intervention without implantation" will become the core of future development. Facing the policy impact of centralized stent mining, it will be an effective hedging means to extend the layout of coronary intervention chain. In addition to completely degradable stents, a new generation of drug-coated balloon (DCB) has also become the core of future development under the new concept of "interventional non-implantation". The data shows that the usage of drug-coated balloons in some hospitals or individuals in Europe has reached 50%-90% of all PCI, and Japan has reached 4,000 per month, accounting for about 15% of Japanese PCI. In addition, auxiliary consumables (balloons, catheters, guide wires, etc.) related to coronary intervention will also become the profit growth point that enterprises pay attention to.

Technical service chain: The further decline in the proportion of consumables in the cost of PCI surgery has prompted enterprises to speed up the layout of medical services and health management sectors. Conditional enterprises will cooperate with primary hospitals to provide equipment consumables, drugs and medical technical services needed for interventional diagnosis and treatment, and promote the grassroots promotion and popularization of new interventional technologies, which will become an important exploration for coronary intervention enterprises to face the centralized procurement of high-value consumables.

On the other hand, the centralized procurement of cardiac stents has prompted enterprises to expand from coronary intervention to peripheral intervention, and continuously enrich their product lines:

Make full use of enterprise stent balloon design and precision manufacturing platform technology, constantly innovate and develop, expand the company’s products from coronary intervention to peripheral intervention, continuously enrich the cardiovascular disease product line, and concentrate on improving the company’s marketing network structure to cope with market risks brought about by policy uncertainty.

Figure 14 Possible business development direction of cardiac stent enterprises under the background of centralized procurement

(C) changes in the market

Under the general trend and background of medical insurance fee control and national centralized procurement, it has a great influence on the competition pattern of domestic medical industry. Medical device enterprises will face more fierce market competition, as well as the realistic problems of product prices and product profit margins falling sharply. For the leading enterprises in the industry, although they can seize more market share by winning the bid at a low price, the problem of shrinking scale and declining profit rate cannot be underestimated.

In the foreseeable future, the scope of domestic medical insurance control fees will only increase, so as to more effectively reduce the pressure of medical insurance expenditure, reduce the prices of drugs and devices and benefit the people’s livelihood. In addition, the situation in the field of devices may appear in the previous pharmaceutical field, and importers may take more aggressive quotations to seize the domestic market after they are familiar with the rules.

For domestic cardiac stent enterprises, facing the policy risks of centralized procurement and medical insurance control, they need to seize the domestic share, turn their attention to the international market and participate in the international market competition. In fact, domestic heart stent head enterprises have also started the international strategic layout, among which minimally invasive medical care, Lepu medical care and Lan Fan medical care are typical representatives.

Turn: Transforming into a strategic choice for heart stent enterprises to overtake in corners.

In the face of major changes in the national medical device policy, cardiac stent enterprises actively predict the development trend, plan ahead, and focus on developing products and new businesses related to centralized procurement while strengthening product technology innovation. For domestic heart stent enterprises, what transformation layouts have been made at present? What is the possible key direction of development in the future?

(1) Adjust the business strategic map and form a multi-sector support system.

1. Diversification of business lines-minimally invasive medical treatment

Through business diversification, we will continuously broaden profit points and enhance comprehensive competitiveness. In recent years, Minimally Invasive Medical Devices Co., Ltd. (hereinafter referred to as "Minimally Invasive Medical") has continuously enriched its product line and expanded its business field through outreach acquisition and endogenous development. Products gradually changed from early cardiovascular stents to diversified business systems covering cardiovascular intervention, orthopedic medical devices, heart rate management (pacemaker), arterial and peripheral vascular intervention, and nerve intervention products.

In 2019, the business revenue was 5.55 billion yuan, of which 33.4% came from cardiovascular interventional products, 29.3% from orthopedic medical devices, 26.3% from heart rhythm management business, 6.1% from arterial and peripheral vascular interventional products, and 3.5% from neurological interventional products. In 2012, the revenue of minimally invasive medical cardiovascular interventional products (stents) accounted for 83.8%.

Figure 15 Comparison of the proportion of minimally invasive medical business segments in 2012 and 2019 (data source: minimally invasive medical annual report)

2. Product line "from one to four", and build a platform business model of "equipment+medicine+medical service+new medical care"-Lepu Medical.

Lepu (Beijing) Medical Devices Co., Ltd. (hereinafter referred to as "Lepu Medical"), as one of the earlier enterprises engaged in the research and development of cardiovascular interventional medical devices in China, has been accelerating the business integration, optimization and layout in recent years, and has developed from a single stent business in 2013 to four business segments covering "devices+drugs+medical services+new medical care" at present, with the goal of building a platform-based business model around the whole life cycle service for cardiovascular patients.

Figure 16 Main contents of each business segment of Lepu Medical

Dual track of medical devices and medicines: In terms of revenue, the revenue of Lepu Medical in 2019 was 7.80 billion yuan, a year-on-year increase of 22.6%. Among them, the medical device sector achieved operating income of 3.62 billion yuan, accounting for 46.4%, and the pharmaceutical sector achieved revenue of 38.5%, accounting for 49.4%. Among them, the revenue of coronary stent system only accounts for 20% of the total revenue of Lepu Medical. In addition, the market share of the company will be directly increased after winning the bid, and the negative impact of centralized procurement is relatively limited.

Figure 17 Revenue Ratio of Lepu Medical in 2019 (Source: Lepu Medical Annual Report)

3. "Health protection+medical equipment" two-wheel drive-Lan Fan Medical

Lan Fan Medical Co., Ltd. (hereinafter referred to as "Lan Fan Medical") is a leading enterprise in the field of medical gloves in the world, accounting for 22% of the global market. In 2018, it successfully acquired the fourth-ranked cardiac stent company in the world, Singapore Baisheng International Group, and realized its layout in the field of medical devices. Subsequently, Lan Fan Medical implemented the "A+X" industrial strategy, and set up four business divisions with a total of seven tracks:

Figure 18 Layout of Lan Fan Medical Industry

At present, Lan Fan Medical has two business series products, namely health protective gloves and heart stents, which are continuously extended to the whole chain of emergency care, cardiovascular and cerebrovascular diseases, forming a multi-business sector collaborative model combining low-value, medium-value and high-value consumables products, with complementary modes and risk hedging. In 2019, Lan Fan Medical achieved a revenue of 3.48 billion yuan, of which the revenue of health protective gloves was 1.68 billion yuan, accounting for 48.3%, and the revenue of cardiac interventional devices (including self-produced and agents) was 1.74 billion yuan, accounting for 50.0%.

Figure 19 Revenue Ratio of Lan Fan Medical in 2019 (Source: Lan Fan Medical Annual Report)

(2) Expand the cardiovascular product chain and form a diversified ecological closed loop.

1. Strategic positioning of big heart-minimally invasive medical treatment

Based on its own existing technology and platform, minimally invasive medical care constantly lays out big heart tracks: coronary heart disease, arrhythmia, structural heart disease and heart failure.

Development contextMinimally invasive medical care started from coronary stent, then cut into radiofrequency ablation, and then extended to pacemaker business. Later, with the further development of interventional technology, structural heart disease entered the era of minimally invasive surgery, and minimally invasive medical care opened up the technical path of completing heart valve replacement by interventional method (representative product VitaFlow transcatheter aortic valve system). Compared with these business units with mature products, Minimally Invasive has begun to "plan the layout" of the treatment solution for heart failure, which is also an important pawn for the future layout of Minimally Invasive and the key to completing the closed loop of the big heart business.

2. Optimize iterative coronary medical devices, enrich and innovate the implantable product line-Lepu Medical.

Lepu Medical has built a rich product group of devices in the cardiovascular field:

1) Accelerate the industrial chain matching of coronary intervention devices. In 2019, Lepu medical coronary stent products achieved operating income of 1.53 billion yuan, a year-on-year increase of 23.3%; Supporting auxiliary consumables (balloon catheter, guide wire, etc.) realized an operating income of 260 million yuan, up 51.0% year-on-year. Under the background that most of the auxiliary PCI interventional materials such as balloon catheter guide wire are monopolized by foreign capital, Lepu Medical is the only R&D and manufacturing enterprise in China that can provide all the consumables for coronary intervention. At present, more than ten necessary consumables such as pre-expanded and post-expanded balloon catheter, PTCA guide wire, guide catheter, contrast guide wire, contrast catheter, sheath, Y valve, triple tee, pressure extension tube, pressure pump, ring handle syringe, pressure sensor and hemostasis compressor have all been mass-produced.

2) Coronary balloon products and NeoVas bioabsorbable stents are expected to form new growth points. In February 2019, NeoVas, an international second-generation bioabsorbable drug stent independently developed by Lepu Medical, was approved for listing in China, and opened a new era of PCI technology "intervention without implantation". In July 2019, the first-generation coronary balloon was approved by GMP for the first time. Three products of the second-generation drug balloon series are about to start clinical trials, and the third-generation rapamycin drug balloon technology has made breakthrough progress, and animal experiments will be carried out soon.

In addition, in recent years, Lepu has actively developed peripheral products of degradable and drug balloons based on the Group’s coronary stent and balloon platform technology, and its business scope has expanded from coronary intervention to peripheral intervention.

3. Layout of coronary artery, valve, nerve intervention and peripheral intervention-Lan Fan Medical.

At the time when the medical device industry entered the golden period of development, Lan Fan Medical continuously accelerated the overall layout of cardiovascular and cerebrovascular devices based on the leading edge of Baisheng International Cardiology Department:

In the field of coronary intervention: all kinds of stent products produced by Singapore Baisheng International are sold to more than 90 countries and regions around the world, with a sales volume of 400,000. At present, BioFreedom, a drug-coated stent of BA9? without polymer carrier, has been introduced into European and Japanese markets, and it is expected to be listed in the United States and China in the near future. From the perspective of stent technology, the upgrading of technology is still the theme of stent industry and the driving force of sales growth. The increase in the proportion of high-end stents such as BioFreedom and Excrossal, as well as the development of foreign markets, have helped to enter the new product bonus period. In addition, taking the cardiac stent as the fulcrum, we will enrich, expand and improve the product line combination related to PCI surgery, such as contrast guide wire, contrast catheter, guide wire, guide catheter, pre-expanded balloon, post-expanded balloon, puncture needle, arterial sheath and pressure extension tube.

Cardiovascular related product lines: Apart from coronary artery, valve, nerve intervention and peripheral intervention are also the tracks that Lan Fan Medical keeps cutting in. By continuously expanding and expanding related product lines such as valve, nerve intervention, peripheral intervention and drug balloon, the competitiveness of product portfolio will be enhanced. The capital is undoubtedly the quickest way for Lan Fan Medical to broaden the track. In June, 2020, Lan Fan Medical acquired the fifth manufacturer of TAVR in the European market. NVT’s main business is the research and development, production and sales of interventional valves for structural heart disease. Through the acquisition of TAVR, a gold track for medical devices, NVT officially entered the field of minimally invasive interventional structural heart disease therapy with broad prospects.

(C) the implementation of internationalization strategy to enhance the international market share of products.

1. Actively deploy the global mainstream market-minimally invasive medical care.

Since 2014, minimally invasive medical care has set its sights on overseas and accelerated the export of China native coronary stents to overseas markets. In 2019, the overseas business of minimally invasive medical drug-eluting stents achieved revenue of 160 million yuan, a year-on-year increase of 72.4%. Sales in 25 countries or regions and registration certificates in 13 countries or regions. Among them, Firebird2TM’s overseas revenue increased by 186.9% year-on-year, FirehawkTM’s revenue increased by 54.6% year-on-year, and it has been sold in several major European countries. In addition, the group has also submitted the application for registration of FirehawkTM stent to the Japanese medical device review and approval authority, and actively deployed the global mainstream market.

Figure 20 Sub-regional Income Ratio of Minimally Invasive Medical Care in 2019 (Source: Minimally Invasive Medical Annual Report)

2. Establish an international business department to increase the market share of international innovative products-Lepu Medical.

Lepu Medical put internationalization on the agenda after the first round of domestic drug collection in 2018, and proposed to further increase the market share of international innovative products. At present, the original foreign trade business and departments of all subsidiaries have been integrated, and the international business department has been established to strengthen the international influence on the upstream and downstream of the medical industry chain in the cardiovascular field. Explore the possibility of setting up R&D centers and production bases overseas. Overseas R&D centers have been planned to accelerate the clinical registration of innovative products (degradable stents, TAVR3.0, renal artery ablation, artificial intelligence ECG and artificial intelligence monitoring) in the world.

It is reported that Lepu Medical’s business revenue from abroad in the first half of 2020 was 870 million yuan, an increase of 320 million yuan compared with the whole year of 2019. Guo Tongjun, senior deputy general manager and secretary of the board of directors of Lepu Medical, said at the reception of listed companies that the company’s overseas market target remains unchanged, and the proportion of overseas market revenue will continue to increase to 20%-30% in the next 3-5 years.

Figure 21 Lepu Medical Internationalization Strategic Measures

summarize

National centralized procurement is not only a reshuffle of the cardiac stent industry, but also an impetus to the cardiovascular segmentation field. Heart stent enterprises still have a long way to go, but whether they are facing the "change" of the industry calmly or actively responding to the "turn" of the industry, there are undoubtedly two ways to go: First, strengthen the technological innovation and product iteration of heart stents in order to obtain new user markets; The second is to realize business diversification and risk hedging with the heart stent as the fulcrum.

The survival simulation card game ＂Card Survival： Fantasy Forest＂ was put on the shelves of Steam.

　　Recently, the survival simulation card game "Card Survival: Fantasy Forest" developed and distributed by WinterSpring Games has been put on the Steam platform. This game does not support Chinese for the time being, and the release date is unknown.

Ranger network 1

The game is introduced:

　　Card Survival: Fantasy Forest Card Survival: Fantasy Forest will be a card-based deep survival simulator and the next game in the card survival series. Create a home with independent will for yourself in the virgin forest. Simulate your daily life in a natural world full of mystery, beauty and cruelty.

Game features:

　　Simple and deep system:

　　Deep and detailed survival simulator based on cards. The card mechanism makes it easy for players to get started and leaves room for imagination to give players a unique experience.

　　All interactions are done by using cards or combining them together.

Living forest ecosystem:

　　Participate in a complex ecosystem, which has the power of dynamic simulation (including animal and plant populations). These forces can operate independently, but they can be meaningfully influenced by your behavior. Experience the cyclical nature of life through four different seasons and a complete weather system.

Realistic simulation system:

　　Simulate digestive and immune systems, wound types and their healing process, and psychological states including anxiety, mania, depression and mental disorders. Track physical and chemical indexes from weight, calluses to diarrhea degree.

Game screenshot:

Ranger 2

Ranger 3

Ranger network 4

Behind the booming live broadcast： three products are flooded, and brushing traffic is frequent.

　　In the past few days, this newspaper has continuously reported the hot situation of live broadcast of goods on e-commerce platforms. Then, is the quality and safety of the goods that consumers buy in the live broadcast room excellent, and can the after-sales rights be guaranteed? Behind the booming live broadcast, how the platform and anchor should be self-disciplined and effectively supervised has become the focus of consumers’ concentrated attention.

　　The advantages and disadvantages of live broadcast products are in doubt.

　　"The price is indeed cheaper than the discount store, but the size and specifications are not the same as the genuine ones." Consumer Mr. Liu told reporters that when he was preparing to place an order to buy a well-known brand sports shoes in the live broadcast room of an e-commerce platform, he found that the 42.5-yard merchants he usually wore did not provide them, and all the optional sizes were integer sizes, and all the "half sizes" were not available. "There are genuine counters in all styles ’ Half size ’ Yes, so I feel that the shoes sold in this live broadcast room are still a bit uneasy. " The reporter learned in the interview that many consumers have doubts about the goods in the live broadcast channel. Mr. Wang, a consumer, said that he saw a mosaic toy during the live broadcast on the e-commerce platform. From the trademark to the packaging box and the theme content of the product set, it was very similar to a well-known brand. On the live broadcast interface, there were even less conspicuous subtitles that were compatible with the building blocks of well-known brands, and the sense of "cottage" was particularly obvious.

　　Is the "original ecology" product reliable?

　　Near the Spring Festival, many agricultural products from rural sellers are very popular in the e-commerce new year promotion activities. Reporters have seen products such as "rural autotrophic pigs", "earth eggs", "farm bacon" and "homemade honey" in the live broadcast rooms of many platforms, but are the quality of these so-called "original ecological" agricultural products directly from the fields really reliable, and is food safety guaranteed? When the reporter communicated with an anchor specializing in "rural autotrophic local pigs", he learned that all the pork, pig liver, pig lungs, etc. sold in the live broadcast room had not been inspected and quarantined. During the live broadcast, the anchor clearly told the reporter that if you want the quarantined pork, you can only go to the supermarket to buy it. The pork sold in his live broadcast room is "self-supporting by farmers" and is now slaughtered and sold without quarantine. In addition, the reporter also saw some bacon, honey, rice wine, etc. recommended by the anchor, which looked good in color and flavor, but it was impossible to know whether the production process and the use of ingredients and additives were standardized.

　　Anchor "self-discipline" can not be ignored

　　The reporter learned in the interview that with the increasing popularity of live broadcast, the "price tag" of some online celebrity anchors has gone up, especially the "head anchor" of live broadcast channels on several major platforms, and the price of live broadcast and anchor commission have been considerable. Therefore, data related to the live broadcast traffic and conversion rate of the anchor commission income are becoming more and more important. According to industry sources, in order to increase the price of the goods and the commission of the anchor, the situation of "brushing the bill" and "brushing the flow" occurs from time to time. This is untrue data for merchants, and to a certain extent, it constitutes false propaganda, misleading consumption, and even a deceptive behavior for consumers. These have become problems that consumers, manufacturers, merchants, platforms and anchors have to face. At the moment when the laws and regulations related to live broadcast delivery are still not perfect, the "self-discipline" of the platform and anchor is particularly important.

　　Our reporter Zhai Weilu

David seidler, the screenwriter of The King’s Speech, died at the age of 86.


1905 movie network news According to foreign media reports, senior screenwriterbigdefendSeideler died at the age of 86. According to his agent, david seidler died while fishing in New Zealand on March 16th, local time. David seidler once relied onThe king’s speechWon the best original screenplay award at the 2010 Oscar, and the film also won the best film, director and leading actor at the current Oscar. He has also written plays for many films, such as Onassis: The Richest Man, Subversion Instruction, Pioneers, Stage Love and Our Days.　


Heading for the new future of people and cars, Guangzhou Automobile Group made its home appearance at the 2023 Guangzhou Auto Show.

　　Guangzhou Automobile Group will bring its complete vehicle brands such as Guangzhou Automobile Chuanqi, Guangzhou Automobile Ai ‘an, Guangzhou Automobile Honda and Guangzhou Automobile Toyota.2.2The "Guangzhou Automobile Pavilion" package pavilion was unveiled. Facing the new era of intelligent vehicles with the deepening of the "new four modernizations", Guangzhou Automobile Group shares a new blueprint for the future life of people and vehicles with a more scientific and forward-looking sense.

　　This time, various car companies under Guangzhou Automobile Group have brought the latest strategy and star products with great sense of science and technology, and made every effort to build a new future for mobile travel. For the first time, GAC Chuanqi unveiled a safer, more efficient and worry-free smart electricity new energy technology brands and a new blueprint for new energy development. At the same time, through the new energy technology of smart electricity, we will break the old framework and improve the new energy vehicles.E9/ES9/E8Strong product matrix, and shadow leopard.RR、M8A series of new works such as Master Pioneer Cockpit Edition shine at home.

　　HaoboHT/TrumpchiES9/TrumpchiE8official listing

　　During the auto show, Guangzhou Automobile Group announced the prices of three new cars in one breath and officially put them on the market.

　　HaoboHTOn the eve of the auto show, new cars were launched.sixModel, price21.39ten thousand-32.99Ten thousand yuan. As the brand’s firstSUVModel, HaoboHTAfter listing, it will officially complete Haoplatinum "cars, sports cars,SUV”The product lineup. It is reported that the new car will be based on Haobo.AEP 3.0 Pure electric platform and Spirit electronic and electrical architecture, with length, width and height of.4935/1920/1700mm, the wheelbase is2935mm, positioned as medium and large pure electricity.SUV.

　　In the appearance part, the design of the new car is very avant-garde, and the shape is more concise. The overall design is close to Haobo.GTThe design language, the rear door of the new car also supports the optional Tesla.Model
XGull wing door of the same model, which reaches2.3mThe opening height of.

　　In terms of configuration, HaoboHTAlso equipped with log handrails,NAPPAMilan’s new luxury cockpit with leather seats can be realized in the back row.143°The largest adjustment angle of the back seat backrest at the same level allows users to lie flat comfortably in the car, bringing zero-pressure stretching enjoyment. In terms of intelligent driving, Hao BoHTHave "high speed"+City "NDAIntelligent navigation assistance system, equipped with33Perceptual hardware, includingthreeA second-generation intelligent zoom lidar,sixA millimeter wave radar,12A long-distance ultrasonic radar and12A camera.

　　HaoboHT The rear drive version uses the maximum power.250 Kilowatt motor, equipped with ternary lithium battery, the official acceleration time of zero hundred is5.8Seconds In addition, Haobo official said: The car will be equipped with the world’s first true.5CFlash charging with750AThe highest charging current in the industry,15It can be charged in minutes450km.

　　TrumpchiES9The listing was launched in total.fourConfiguration, official price22.98-26.98Ten thousand yuan, simultaneously launched the "full brand replacement to enjoy.2Ten thousand subsidies ","fiveyear1510,000 km vehicle warranty,Sandian Lifetime Warranty ","24Hours of direct connection service,24Six major car purchase rights, including "hourly road rescue", "charging pile delivery and installation service" and "free basic flow for life", provide users with all-round car purchase protection. In addition, Chuanqi also intimately launched the "New Energy Test Drive Season" activity, that is,11mooneightsun-30On, customers who come to the store to test drive this model for the first time can enjoy the test drive gift.

　　TrumpchiES9Traveler and dragon scale wing can be provided with optional double appearance shapes, and the penetrating waistline connects the front and rear lamp corners, which lengthens the visual length of the side of the car body. The rear of the car is designed with a "small schoolbag" for storage space. In terms of body size, the new car length is5015mm(Long Lin wing)/5110mm(Traveler), Kuan1976mm , high1780mm, the wheelbase is2920mm. The new car can also providesix Zuoheseven Block version.

　　TrumpchiES9 Equipped with GAC self-research2.0TM Hybrid special engine+ GMC400 Special gearbox for hybrid power+PHEV Special power battery. Among them,2.0TMaximum engine power140kW, peak torque330Nm.CLTCComprehensive cruising range1215 Kilometers,CLTCPure battery life143 Kilometers.

　　TrumpchiE8Also officially announced the pre-sale price, for20.98-22.98Ten thousand yuan, and in12Officially delivered in June. The new car is positioned as a medium-sized hybrid new energy source.MPV, located in ChuanqiE9Under. Appearance, ChuanqiE8Still standard.MPVStyle design, chuanqiE8Length, width and height are respectively4920mm、1900mm、1760mm, wheelbase2930mm. New car adoption2+2+3The advantage of this design is that it is convenient to get in and out of the third row, but for families with two children, three independent seats in the back row are more advantageous.

　　TrumpchiE8pick up2.0LNaturally aspirated Atkinson cycle engine+Plug-in hybrid power system composed of motors, maximum engine power103kw, peak torque180NmMaximum power of motor134kw, peak torque300Nm, match2resist/cover/fenderDHTHybrid special gearbox,CLTCOperating mode pure electric cruising range150Kilometers. In terms of chassis structure, ChuanqiE8Adopt front McPherson independent and rear torsion beam dependent suspension.

　　Brand new concept carERAera+First production of solid-state batteries

　　Guangzhou Automobile Group released its brand-new concept car-ERAEra. At the same time, the official release of new progress in solid-state batteries, its cell energy density reached.400Wh/kgIt can meet the safety and reliability requirements of the battery in extreme environment.

　　In terms of appearance,ERAEra adopts a brand-new design style, in which honeycomb elements are added into the enclosed front grille, with the overhead penetrating light strips and luminous brands.LOGOAt the same time, it also increases the visual layering of vehicles. Viewed from the side of the car body, the car adopts the opposite door design, which greatly improves the convenience for vehicle personnel to get on and off. At the same time, the addition of six-spoke low wind resistance rim also optimizes the wind resistance coefficient appropriately. In terms of motivation, the official has not released specific information at present.

　　Feng Xingya, general manager of Guangzhou Automobile Group, said that solid-state batteries, cobalt-free batteries, low-cobalt batteries and sodium ion batteries will be included in the key technical research of Guangzhou Automobile’s self-developed batteries. Among them, solid-state batteries have made breakthrough progress, and the energy density of batteries has reached400Wh/KgIt can meet the safety and reliability requirements of the battery in extreme environment. "Our goal is to2026All-solid-state battery loading was realized in. "Feng Xingya revealed. In addition, investment109hundred million yuan36GWhThe first factory of Yinpai battery will be mass-produced at the end of this month.

　　Text/Xu Fanghua

The Indian government falsely claimed that China’s mobile phone stole information to conduct a large-scale review.

　　Overseas networkAugust 16 th According to Indian media reports, the Indian government issued a warning to various mobile phone manufacturers in China for rectification within a time limit on the grounds of "worrying about data leakage endangering security", and began a large-scale review of electronic products imported from China.

　　According to the Times of India,The Indian government "suspects that China mobile phone manufacturers are stealing users’ information", such as contact lists and short messages, falsely claiming that they are engaged in "hacking", and issued a warning to the major smartphone manufacturers in China for rectification within a time limit.

　　Although Apple, Samsung and Indian mobile phone manufacturers received similar notices, most of them were China mobile phone brands. According to reports, the warning was issued by the Indian Telecommunications Bureau, and a total of 21 companies were notified.

　　The Indian media quoted an Indian official as saying, "The government requires these companies to carry out rectification in accordance with India’s safety provisions before August 28, and the government may also conduct audits to ensure that they comply with relevant regulations." The official also said that "if these companies are found to be in violation of regulations, they will be fined".

　　According to The Times of India,The Indian government has started a large-scale review of electronic products imported from China on the grounds of "worrying about data leakage endangering security".

　　A recent study by Indian Industry Group shows that the market value of China enterprises in India’s emerging telecommunications industry is increasing, reaching nearly $22 billion, which has aroused a strong reaction within the Indian government. They think that these China enterprises may illegally obtain information of individuals, enterprises and government agencies. According to reports, an internal government source said, "IndiaThe government believes that many electronic devices in China transmit or store data in servers in China, which may bring security risks, especially when the border tension between the two countries increases."

　　This is not the first time that India has cracked down on China products. According to overseas reports, the Indian government announced on August 9th local time that it would impose anti-dumping duties on 93 kinds of products imported from China.

　　According to Indian media reports, the trade balance between China and China is tilted towards China, and the trade deficit has reached 51.09 billion US dollars (about 339.8 billion RMB). A large number of goods imported from China flooded the Indian market, and’s smart phones have won "half of the country" locally, which has greatly hit the local industry. Earlier, a survey agency in India released a report saying that Indian consumers are more willing to buy China goods than local Indian goods. The report quoted the interviewees as saying that among similar products, Indian-made products are expensive, while China products have the most advantages in price and good quality.

　　Gao Feng, spokesman of China’s Ministry of Commerce, revealed last month that in the first half of this year, India has launched 12 trade investigations against China, once again becoming the country with the largest number of trade investigations against China.

　　According to the 2016 China-India Bilateral Trade Report released by the Indian Embassy in China in February this year, China has replaced the United States and the United Arab Emirates as India’s largest trading partner and the largest source of imports. In 2016, the trade volume between China and India reached US$ 71.18 billion, including US$ 11.75 billion in exports and US$ 59.43 billion in imports. India’s trade deficit with China was US$ 47.68 billion.

　　Lan Jianxue, an expert on South Asia at the China Institute of International Studies and a former diplomat in India, said that China has been a key target country for India’s anti-dumping for many years, and it has always been so. However, he stressed that in view of the current tense confrontation between China and India, India’s adoption of this measure at this time does not rule out catering to the extreme anti-China sentiment in its own country. (Compile/Overseas Network Yang Jia)

[Video] The passenger’s mobile phone was fined by the police, 200 yuan.

　　　　CCTV News:Click to watch the video > > >







　　　　Police officers found obscene videos on mobile phones when checking tickets.


　　　　Yesterday morning, as soon as Tang Shanghai and his friend Chen Haijun returned to Chongqing from Huaihua, they introduced to reporters that Tang Shanghai was fined by a police officer on September 18th for storing a yellow video on his mobile phone.


　　　　According to reports, at 10: 30 am on September 18th, Tang Shanghai, who lives in Loufang Village, Taihe Town, Hechuan District, and his friend Chen Haijun took the K531 train from Chongqing to Hangzhou to Huaihua. At 1 o’clock in the morning on the 19 th, a policeman began to check tickets in the carriage.


　　　　"We took out tickets, wallets, mobile phones, etc. from our purses for him to check." Chen Haijun said that the policeman found that Tang Shanghai’s mobile phone was the same style as the one he used, so he opened it without authorization and skillfully checked various functions. Unexpectedly, the policeman found that there was a yellow video in the mobile phone. "Why do you have yellow videos on your mobile phone?" The policeman’s loud questioning made the surrounding male and female passengers stare at Tang Shanghai. "I was blushing and my neck was thick, and I felt ashamed." Tang said that he is over 40 years old, so he often watches obscene videos. He was afraid that passengers would think he was lewd.


　　　　Second, the mobile phone comes with porn, and the police call 500 yuan for punishment


　　　　Subsequently, the policeman ordered him to take his mobile phone and followed him to the restaurant carriage. After handling four or five fare evasion passengers, the police took him to an office. Tang said that he always explained to the police that he didn’t download the obscene video, but that when he bought a second-hand mobile phone, it had a yellow video of about 4 minutes on it, and he didn’t show it to anyone. However, the police still demanded a fine for 500 yuan on the grounds that Tang copied and disseminated obscene videos privately, and said: "You can do it without paying a fine. When you arrive at the next station, you will be handed over to the local station police station for administrative detention."


　　　　"I was scared when I heard it, and I quickly pleaded with him." Tang said that he begged for a long time, and finally the policeman still fined him 200 yuan and asked him to write down the inspection book on the spot.


　　　　Think that improper handling of passenger telephone complaints


　　　　At 2 o’clock in the morning on the 19th, Tang Shanghai and his friend Chen Haijun, who were more and more wrong, immediately complained to the police detachment of the Public Security Department of Hangzhou Railway Branch of Shanghai Railway Bureau that the police had not handled it properly. At about 6: 50 in the morning, Fang Instructor of the Police Detachment of the Public Security Department of Hangzhou Railway Branch of Shanghai Railway Bureau took the initiative to call Tang and Chen and explained that their police handling was legal and correct, but apologized to Tang Shanghai for the way and attitude of police handling.

[Industry observation in the post-epidemic era] After May Day, there may not be many people who invite you to ＂learn about fitness swimming＂.

　　Cctv news(Reporter Zhu Chunyan) "If you don’t lose weight in March, you will be sad in April". Every year in March and April, it is a good time for gyms to engage in sales, but this year is different due to the epidemic situation. Will the gym that missed this spring usher in the peak season in May?

　　Wear a mask to keep fit.

　　On April 30th, Liu Jian, a fitness coach, finished exercising in his fitness studio and picked up disinfectant to kill bacteria. "I’m finally ready to welcome members". During this time, he always went to the studio to exercise alone, and then closed the door and left. He joked that it was spending tens of thousands of dollars every month to configure a luxury gym for himself. Liu Jian’s fitness studio is located in Chaoyang District, Beijing. It was closed during the epidemic and is expected to reopen in early May.

Yun fitness

　　As the epidemic situation eased, many gyms opened one after another. Mr. Wu, the head of public relations for Super Orangutan, a chain fitness institution, told the reporter that half of the more than 100 classrooms of Super Orangutan in eight cities across the country have been approved and accepted by various places and started to resume business. During the epidemic period, the business should implement systematic epidemic prevention and control measures. When members enter the store, they must take temperature measurement, register their real names, check their health codes, etc., and increase store housekeepers to do cleaning, disinfection and hygiene management.

　　The reporter learned that many yoga studios in Beijing will also open for business. Phoenix Yoga staff said that after the class started on May 1st, the number of members in the class was strictly limited. Previously, the class that accommodated more than 40 people was changed to a maximum of 15 people, and members also needed to carry their own yoga mats to go to class. Yoga mats, towels, cups, etc. were no longer provided in the venue. She said that the venue has arranged to disinfect classrooms, auxiliary rooms, dressing rooms, public areas and toilets at regular intervals every day.

　　According to the Work Plan on Safe and Orderly Opening of Sports and Fitness Facilities in novel coronavirus during the Epidemic Period issued by Beijing Municipal Sports Bureau, at present, except swimming pools and underground sports and fitness facilities, other indoor sports and fitness facilities can be reopened.

　　Dapeng, the coach of an underground swimming and fitness venue in Beijing’s West Third Ring Road, told reporters that the membership card will be postponed. As for when the gym will open, the company is also waiting for a policy notice. Dapeng said that at this time in previous years, he would go out to hand out leaflets after giving lessons to members, "Learn about fitness swimming", but he has been unemployed at home since the Spring Festival holiday this year. Dapeng said that the company didn’t do anything during this time. "The boss has other business." In fact, he himself is not sure whether he can return to this gym to continue his work.

　　The life-saving straw "Cloud Fitness" will not stop.

　　On January 30th, the State Sports General Administration issued the Notice on Vigorously Promoting Scientific Fitness at Home, actively advocating scientific fitness at home. For each gym, driving home fitness has also become a lifeline for enterprises to survive.

　　The Music Carving Campaign, which focuses on private and small class teaching, has about 500 stores nationwide. After offline suspension, it spends tens of millions every month. Han Wei, the founder, predicted that the epidemic would cost Leke at least 100 million yuan, or even several times. During the Spring Festival, Han Wei assembled 100 employees to form a "death squad" to carry out online business, including recording and broadcasting small videos, live broadcasting and offering special courses, which were launched on platforms such as Aauto Quicker and Tik Tok. Yang Shuting, the public relations director of Leke, said: "Online live broadcast has broken the barriers of time and space and attracted a large number of users."

　　"Cloud Fitness" has become a must-have at home for a time. The super orangutan opened the "Super Scarlet Squat in the Home" on a live APP, and the number of online users in the first live broadcast exceeded 170,000, becoming the TOP1 anchor on a live broadcast. Mr. Wu, the head of public relations for Super Orangutan, said that with the arrival of the resumption of work, the number of viewers during this period was less than that in the early days, about 50,000 people per game, and many users have developed the habit of watching live exercises together.

Yun fitness k

　　With the growth of users, "cloud fitness" has not only become a lifeline for gyms, but also attracted a large number of giants from outside the industry. Alibaba Entertainment, Suning, etc. also joined their sports institutions to continuously launch videos and live broadcasts of fitness guidance on the online platform.

　　For fitness coaches, "cloud fitness" is a challenge, and it also gives them more room to play. During the epidemic, Keepland opened a "cloud small class" to allow coaches to start classes online in the form of a two-way camera. Coach Wang Wei said that he has never adapted to enjoying "small classes in the cloud" now. "Although his income is not as good as usual, he is more motivated to use his own training logic to attend classes."

　　Probe into the boundary of fitness industry

　　Although the income of online teaching is far less than that of offline courses, many insiders said that online exploration has cultivated people’s habit of online consumption, and offline is still the best fitness choice in the future, but online will also be indispensable. Online and offline access will become a new direction of the fitness industry.

　　He Wenyi, executive director of China Sports Industry Research Center in Peking University, believes that if the fitness industry wants to innovate and upgrade, it is necessary to seize the opportunities and challenges in the epidemic, or it may be eliminated. The so-called opportunity is that it is very important for the fitness industry to grasp the innovation of fitness content and products after the epidemic has made people pay enough attention to health.

Yun fitness

　　The manager of a gym store in Beijing said that due to the epidemic, the physical store could not operate normally, but the company launched the "2020 Anti-epidemic Memorial Card" to upgrade and innovate its products. In addition, online celebrity Store was launched earlier to explore the fitness venues in the new media era, making it a lifestyle platform, a club and a new social place.

　　Han Wei, the founder of Leke, summed up the model of the gym into three versions: 1.0 model, opening a store to earn money from a store; 2.0 mode, establishing an online platform mode to connect users with offline gyms; 3.0 mode, after establishing the online platform, self-operated offline stores, "connecting people and goods yards, and making money offline".

　　In the post-epidemic era, fewer people may invite you to "learn about fitness swimming" on the street, but there may be more and more advertisements recommending you to "buy chicken breast" on the mobile APP.

Its film arrangement is only 0.7%, but it is the most worth seeing in the near future.

Special feature of 1905 film network Have you ever wondered what it would be like if your memory disappeared one day?

We have seen too many movies, and we often meet people whose memories are fading away, and some incredible things have happened. Some people rely on their only remaining memories to find clues to solve crimes; Some people hit their heads and all their memories were restored; Some people can’t get their memories back all their lives.

On February 23rd, the movie officially released in the mainland cinema once again took the memory as a knife. However, this time it is a little different.

1 What’s the difference between this film?

The main characters in the film "Love Before Memory Dies" are two old people. Ella Spencer played by helen mirren is a rebellious old girl, while John Spencer played by donald sutherland is a forgetful old warm man.

The old couple are both seriously ill. John has Alzheimer’s disease, which we often call Alzheimer’s disease. The disease makes his memory go wrong and slowly disappears. He needs to live in a nursing home, while Ella has cancer and needs to be admitted to the hospital. At this moment, the two will face eternal separation.

So, the two decided to take a trip in an RV. The English name of the film "The Leisure Seeker" is the name of this RV — — Leisure seekers. They walked all the way from Massachusetts to the south, recalling the experience of spending their holidays with children. This time, their destination was Hemingway’s former residence on Sisuo Island.

I went to Hemingway’s former residence because John’s favorite writer was Hemingway. At the same time, John is also a teacher. His illness makes him forget the names of his wife and children, but he can easily say Hemingway’s works. Hemingway’s famous The Old Man and the Sea was finished here in Xisuo Island, and it is John’s favorite work.

Two old men "ran away from home" behind their children’s backs. John couldn’t drive because of illness, but during the journey, he drove the old car at a gallop. When Ella called the children, she told them, "Son, we won’t be long. There are some things that I must finish with your father.".

The film fills in the grief and sadness that Alzheimer’s disease would have brought to the family with a lot of jokes, making the whole film easy and interesting.

During the trip, John left his wife alone and drove away. When Ella got on a passerby’s motorcycle and caught up with John, John’s reaction was, "Why are you sitting on a motorcycle?" He has completely forgotten that his wife traveled by car with him.

Similarly, when he arrived in Pennsylvania, he asked Ella, "Where are we?" After Ella told him, he asked, "What are we doing in Pennsylvania?" He will forget his children, mistake his students, and forget the purpose of this trip.

However, he can’t forget English grammar. On the way, when they were forced to hand over the money by a sudden robber, he did not forget to correct the grammatical mistakes made by the robber. At this time, Ella scared away the robbers with a prepared shotgun.

"Love Before Memory Dies" is adapted from Michael Sadrian’s novel of the same name. As a road movie, it reveals the story of travel and uncovers an old story (not much to say, it will be spoiled if you talk too much! ), and behind this past, the focus is on marriage and old age.

In the last period of life, their attitude is not negative at all, and life is full of interest everywhere. Ella, played by helen mirren, painted her nails, wore a wig and put on lipstick. Even though she is not young, she is still a delicate woman. During the journey, the two will also look at old photos with slides.

From the preview, we can also see that the two spent a beautiful and romantic night in the hotel suite. John talked to ella to the fullest; "I can’t believe my wife is so beautiful", the gentleman invited her and they embraced and danced together. The couple who have been together for fifty years have a very funny and warm daily life, and their love is indestructible in the face of aging and death.

The two leading actors won numerous awards.

"Love Before Memory Disappears" was selected as the main competition unit of Venice Film Festival in 2017. After the premiere of the film festival, some media reporters praised helen mirren’s performance. Helen mirren won the Best Actress at the Venice Film Festival in 2006 for her film, and won the Oscar for Best Actress for The Queen the following year.

Helen mirren in The Queen is noble and solemn, but very conservative. When helen mirren portrays Elizabeth II after learning of Princess Diana’s death, she reminds herself by saying "I am the queen" every day. And her superb acting skills have been greatly affirmed.

In addition, helen mirren won the Best Actress Award at Cannes Film Festival with and twice.

Donald sutherland, the actor, should be the most familiar Canadian in China. He is also quite powerful. He is the winner of the 90th Oscar Lifetime Achievement Award. Previously, he won the Golden Globe Award for Best Supporting Actor twice for Citizen X and War Path.

Donald sutherland has appeared in many films, including series,,, and so on. It is worth noting that he once appeared in the works directed by Xiaogang Feng in 2001. His role is Taylor, the great Hollywood director who came to China to make a film.

It can be said that the performances of donald sutherland and helen mirren were impeccable. Many foreign media commented on "Love Before Memory Dies", although they were quite critical of the film’s plays, they still affirmed the performance of these two drama bones, saying that this is the most attractive part of the film, which is quite convincing. "Every wrinkle is a play, and every expression contains the most complicated emotions in the character’s heart."

3 Italian local teams shoot American films.

Paolo Virzì, the director of Love Before Memory Dies, has shot many Italian local comedies, and can be said to be one of the representative figures. His "My name is Tanino" has all been shortlisted for the Venice Film Festival. "Love Before Memory Dies" is the fourth time that he has been selected for the Venice Film Festival.

But his international fame is not very great. In the 74th Venice Film Festival, many famous directors gathered, and his works also received a lot of attention. Especially with the blessing of the two leading actors, the judges can feel the more delicate emotional expression.

Paolo Virzì never thought that he would make a film that had nothing to do with Italy. When he was invited by an American film producer, he decided that helen mirren and donald sutherland must play the roles.

He said: "When I was filming this film as an American director, I always reminded myself of my Italian identity. On the set, I felt the common feelings of human beings. I tried to look at this story from an Italian perspective, and I kept my own style: shooting this film with a story that is true, human, ironic and mixed with comedy and tragedy. "

Yes, this is the concept that Paolo Virzì has always adhered to: there is always tragedy in comedy, and only dramatic plots can make people laugh.

The foreign media "SSG Syndicate" described the film as a bittersweet and warm journey, and the excellent performance made this film. Film Journal International commented that although this film is a bit ordinary, it is very enjoyable in most cases.

When talking about this film, "CineVue" said: "Sorrow and sadness are often dangerous, but" Love Before Memory Dies "is not like this. Even if love comes to an end, they are still celebrating." The critics of RogerEbert.com even shed tears when watching it.

In addition, although the film was shot in the United States, most of the film’s creative team are Italian. Photographer Luca Bigazzi has worked with Italian director paolo sorrentino in many film and television dramas.

Musician Carlo Wizz and director Paolo Virzì are old partners, and he has participated in Osodo and My Name is Tanino.

Editor Jacob Quadri worked with the director on My Name is Tanino, but he is famous for working with Italian director bernardo bertolucci.

The new municipal government held a press conference on the practical project for the people in 2022： vigorously implement the ＂100 thousand＂ action of serving people’s livelihood and better make peop

　　People’s livelihood is no small matter, and branches and leaves are always related to love.

　　On the evening of March 18th, the Municipal People’s Congress and the Municipal People’s Congress just concluded successfully. After the award ceremony of the second "People’s Heart Project Award" in Wuxi, the new municipal government immediately held a press conference on Wuxi’s practical projects for the people in 2022. The newly elected mayor Zhao Jianjun introduced the main measures of people’s livelihood work in our city in recent years and more than 100 practical projects for the people in 10 categories this year.

　　He stressed that it is necessary to consistently strengthen the people’s stand and sense of purpose, put it into action at the first time, coordinate practical projects for the people, "micro-happiness" livelihood projects and "Mayor Online People’s Voice Message Board", vigorously implement the "100 thousand" action of serving the people’s livelihood, continue to promote the solution of the people’s "urgent difficulties and worries" and better make the people’s livelihood work on the hearts of the people.

　　Jiang Min, member of the Standing Committee of the Municipal Party Committee and executive deputy mayor, presided over the conference, and vice mayors Jang Jin, Qin Yongqian, Zhang Lijun, Ma Liang, Zhou Wendong and Min Lu, and secretary general of the municipal government Chen Shoubin attended the conference.

　　Zhao Jianjun said.

　　In recent years, the municipal government insists on doing a good job in people’s livelihood as an important practice to fulfill the initial mission and the key to improve the well-being of the people. It carefully plans a batch every year, collects a batch extensively every year, and completes a batch efficiently every year. The key points are highlighted."one two three"：

　　"One" means to insist on a goal.

　　Through the implementation of a real livelihood, we will continue to satisfy the people’s longing for a better life and accelerate the construction of a common, prosperous and happy city that the people are satisfied with.

　　"Two" means grasping two dimensions.

　　The first is to strengthen overall planning.Focus on major livelihood issues of concern to the masses and implement a number of practical projects for the people;

　　The second is to pay attention to the point of force.Relying on the "micro-happiness" livelihood project and the "Mayor Online People’s Voice Message Board" and other platforms, everyone’s "troubles" and reasonable demands are quickly responded and resolved in time.

　　"Three" means following three principles.

　　First, insist on co-construction and sharing.Adhere to development for the people, development depends on the people, and development results are shared by the people, so that people’s livelihood work is given priority, priority investment, and priority promotion;

　　The second is to adhere to demand orientation.Take the people’s expectations as the political direction, put yourself in the people’s cold and warm demands, and try to help the people solve problems;

　　The third is to persist in pragmatic efforts., strengthen the big picture, small start, practical efforts, do your best and do what you can to do the "top priority" and "key small things" that the masses care about.

　　Zhao Jianjun said.

　　The new municipal government will adhere to and understand the people-centered development thought, strengthen organizational advancement, strengthen follow-up and effectiveness, resolutely do practical things and do good things well, and strive to make the people’s sense of gain more complete and happiness more sustainable in accordance with the established road map, timetable and task book.

　　I believe that under the strong leadership of the provincial party committee, the provincial government and the municipal party committee, with the good foundation laid by previous municipal governments, the joint efforts of the whole city and the care and support from all walks of life, the development of Wuxi will be better and better, the lives of ordinary people will be happier, and there will be more and more smiles on their faces.

　　The press conference interpreted the "100 thousand" action of people’s livelihood service.

　　"Ten" is the first time this year after the implementation of the people’s livelihood and practical projects, the NPC deputies voted for it.10 itemsKey livelihood projects, specifically:

　　◆ Livable environment renovation project

　　◆ Upgrading and reconstruction project of living facilities.

　　◆ Health and health care project

　　◆ Public space beautification and upgrading project

　　◆ Upgrading and reconstruction project of sanitation facilities

　　◆ Rail Transit Construction Project

　　◆ Medical facilities upgrading construction project

　　◆ Beautiful rivers and lakes construction project

　　◆ Green low-carbon smart travel project

　　◆ Expansion and quality improvement project of educational science popularization.

　　"Hundred" is the practical arrangement for the people this year.100more thanSpecific matters;

　　"Thousands" means helping the masses to do well.More than a thousand pieces"Micro-happiness" People’s Livelihood Project, "Mayor Online People’s Voice Message Board" Appeal Matters.

　　In order to promote the long-term implementation of the normalization and institutionalization of the "100 thousand" action of people’s livelihood services, the new municipal government has compiled the "Implementation Plan for the" 100 thousand "action of people’s livelihood services in 2022", which will be issued and implemented in the near future.

　　It is reported that the "micro-happiness" livelihood project was launched in November 2020 and was well received by the masses. Last year, 1,291 items were all completed, and the satisfaction rate of the masses reached 100%; The "Mayor Online People’s Voice Message Board", which was launched at the beginning of this year, has received 4084 messages from the public since it was launched for more than two months, including 3137 messages on appeals, with a response completion rate of 85.8%, and 947 messages on suggestions have been transferred to relevant parties for careful study.