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The General Office of the Ministry of Transport issued the ＂Guide to Transport Safety Services for Self-driving Cars (Trial)＂

Cctv news: The General Office of the Ministry of Transport issued the Guide to Transport Safety Services for Self-driving Vehicles (Trial). It is clear that the use of self-driving cars to engage in urban bus and tram passenger transport, taxi passenger transport, road passenger transport and road cargo transport should adhere to the principles of compliance with laws and regulations, honesty and trustworthiness, safety first and innovation drive. The transportation management of self-driving cars should adhere to the principles of safety first, integrity and innovation, inclusiveness and openness, and orderly advancement.

Self-driving car transport safety service guide (Trial)

In order to guide the development of autonomous driving technology and standardize the application of autonomous vehicles in the field of transportation services, this guide is formulated in accordance with the laws and regulations such as the Law of People’s Republic of China (PRC) on Safety in Production, the Law of the People’s Republic of China on Road Traffic Safety, the Regulations of the People’s Republic of China on Road Transportation, and the relevant provisions on road transportation and urban passenger transport management.

I. Scope of application

These Guidelines shall apply to those who use self-driving cars to engage in urban bus and tram passenger transport, taxi passenger transport, road passenger transport and road cargo transport business activities on urban roads, highways and other roads used for social motor vehicles.

The self-driving cars mentioned in this guide refer to cars that have the ability to perform all dynamic driving tasks under the design and operation conditions according to the relevant national standards and are included in the product access scope by the industrial and information departments, including conditional self-driving cars, highly self-driving cars and fully self-driving cars specified in the national standard "Classification of Automobile Driving Automation" (GB/T40429-2021).

Second, the basic principles

Using self-driving cars to engage in urban bus and tram passenger transport, taxi passenger transport, road passenger transport and road cargo transport (hereinafter referred to as self-driving transport) should adhere to the principles of compliance with laws and regulations, honesty and trustworthiness, safety first and innovation drive. The transportation management of self-driving cars should adhere to the principles of safety first, integrity and innovation, inclusiveness and openness, and orderly advancement.

Third, the application scenario

In order to ensure transportation safety, self-driving cars should carry out road transportation services in designated areas and pass the road traffic safety assessment according to law. Using self-driving cars to engage in urban bus and tram passenger transport business activities can be carried out in a physically closed, relatively closed or simple fixed line and traffic safety controllable scene; Using self-driving cars to engage in taxi passenger transport business activities can be carried out in the scene of good traffic conditions and controllable traffic safety; Prudent use of self-driving cars to engage in road passenger transport business activities; Self-driving cars can be used to engage in road cargo transportation business activities in scenes such as point-to-point trunk road transportation or urban roads with controllable traffic safety; It is forbidden to use self-driving cars to engage in road dangerous goods transportation business activities.

Four, automatic driving transport operators

Operators who use self-driving cars to engage in urban bus and tram passenger transport, taxi passenger transport, road passenger transport and road cargo transport (hereinafter referred to as self-driving transport operators) shall register market entities according to law, and their business scope shall register corresponding business categories; Taxi passenger transport (network car) and road passenger transport should be insured with carrier liability insurance according to law. Those who engage in the operation of urban public buses and trams shall meet the relevant operational requirements of the state and the people’s government of the city where they operate. Engaged in taxi passenger transport, road passenger transport business, road cargo transport business, should have the business license qualification of the corresponding business category. Urban passenger transport enterprises and road transport enterprises can form a consortium with automobile production enterprises to carry out self-driving transport operations. Self-driving transport operators shall go through the relevant formalities according to law, and local transportation authorities shall provide handling channels for self-driving transport operators to engage in self-driving automobile transport business services.

V. Transport vehicles

Self-driving cars engaged in road transport business should meet the requirements of relevant national standards and technical specifications, register motor vehicles according to law, and obtain motor vehicle number plates and motor vehicle driving licenses. Self-driving cars engaged in urban bus and tram passenger transport should meet the relevant operational requirements of the state and the people’s government of the city where they operate. Self-driving cars engaged in taxi passenger transport, road passenger transport and road cargo transport should also meet the requirements of the technical standards for the safety of operating motor vehicles in the transportation industry, and obtain the Network Appointment Taxi Transport Certificate or Road Transport Certificate issued by the transportation authorities at the place of operation according to law. If the self-driving car needs to change the automatic driving function and upgrade the vehicle software system, it should be implemented in accordance with the regulations of the industrial and information departments to ensure the safe operation of the vehicle.

Self-driving cars engaged in road transport business shall provide traffic accident liability compulsory insurance certificate, traffic accident liability insurance certificate or accident compensation guarantee in accordance with the relevant requirements of Road Traffic Safety Law of the People’s Republic of China, Regulations of the People’s Republic of China on Road Transport, Regulations on Compulsory Insurance of Motor Vehicle Traffic Accident Liability and Notice of the Ministry of Industry and Information Technology and the Ministry of Public Security on Printing and Distributing the Management Specification for Road Testing and Demonstration Application of Intelligent Networked Vehicles (Trial) (No.97 [2021] of the Ministry of Industry and Information Technology).

VI. Staffing

Self-driving cars engaged in urban bus and tram passenger transport and road passenger transport should be equipped with a driver or operation safety guarantee personnel (hereinafter referred to as "safety officers"). Self-driving cars engaged in road freight transportation are equipped with safety officers on board in principle. Conditional self-driving cars and highly self-driving cars engaged in taxi passenger transport should be equipped with a safety officer; Fully self-driving cars engaged in taxi passenger transport can use remote safety officers when operating in designated areas with the consent of the people’s governments of districts and cities under the premise of ensuring safety, and the ratio of remote safety officers to vehicles shall not be less than 1:3. Safety officers shall receive training in self-driving car technology and related transportation business, be familiar with the provisions of road traffic safety laws and regulations, the operation skills of different levels of self-driving systems, be familiar with the running routes of self-driving cars, and have the ability to take over vehicles in an emergency. After the automatic driving function of self-driving cars is changed or updated and upgraded, the self-driving transport operators should strengthen the on-the-job training of safety officers in time to ensure that they can master new functions, new technologies and new requirements in time. Safety personnel shall comply with the relevant regulations and requirements for the management of employees in the field of transportation and obtain the qualifications of corresponding business categories.

VII. Safety and security

(1) Safety production system.

Self-driving transport operators should fulfill the main responsibility of production safety, and establish and implement operational safety management systems, including but not limited to the responsibility system for all employees’ production safety, vehicle technical management system, safety evaluation system, safety hidden danger investigation and management system, dynamic monitoring management system, network safety management system, employee safety management system, key post safety operation procedures, safety production and emergency response education and training plan, etc.

(2) Transportation security.

Self-driving transport operators should establish and improve the transport safety guarantee system. Before the formal operation, they should formulate the transport safety guarantee scheme for self-driving vehicles, and clarify the design and operation conditions, staffing, operational safety risk list, grading control measures and emergency response measures of self-driving vehicles. Self-driving transport operators should sign agreements with automobile production enterprises and safety officers, clarify the rights, responsibilities and obligations of all parties, and organize professional demonstration and safety risk assessment of transport safety guarantee schemes. The transportation safety guarantee scheme and safety risk assessment report shall be informed to the transportation authorities, public security traffic police departments and emergency management departments at the place of operation. Self-driving transport operators should ensure transport safety; If there are major hidden dangers that cannot guarantee transportation safety, the automatic driving transportation operation should be suspended in time according to law.

(3) Operation status information management.

Self-driving transport operators should ensure that the vehicle is in good technical condition and operate according to the vehicle instruction manual. Self-driving cars engaged in road transport business should have the functions of recording, storing and transmitting vehicle running state information, and transmit key running state information to the self-driving transport operators and relevant competent departments in the operation area in real time. When an accident happens to a vehicle or the automatic driving function fails, the running state information of at least 90 seconds before the accident should be automatically recorded and stored. The running status information includes but is not limited to the following 10 items: vehicle identification (frame number or vehicle number plate information, etc.); Vehicle control mode; Vehicle position; Motion states such as vehicle speed, acceleration and driving direction; Environmental perception and response state; Real-time status of vehicle lights and signals; 360-degree video monitoring outside the vehicle; In-vehicle video and voice monitoring that reflects the state of human-computer interaction between the driver and the vehicle; Remote control instructions received by the vehicle (if any) and vehicle fault conditions (if any).

(4) Vehicle dynamic monitoring.

If the vehicle conforms to the Measures for the Dynamic Supervision and Management of Road Transport Vehicles and the relevant provisions of the state, it is necessary to strengthen the dynamic monitoring of self-driving vehicles, monitor and manage the vehicle operation area, operation line and operation status, and promptly remind and correct and deal with illegal acts. The transportation authorities at the place of operation should urge the self-driving transport operators to strengthen the dynamic management of transport vehicles and safety personnel.

(5) Safety notification.

Self-driving cars should be marked with eye-catching patterns, words or colors on the body to clearly inform other traffic participants of their self-driving status. Operators who use self-driving cars to engage in urban bus and tram passenger transport, taxi passenger transport and road passenger transport should inform passengers of the automatic driving function, safe riding knowledge, the use of safety facilities, emergency escape methods and other matters by playing videos or posting signs.

(6) Emergency handling.

Self-driving transport operators should formulate emergency plans for the operation of self-driving cars, clarify the types and levels of emergencies, disposal methods, emergency response procedures, division of responsibilities and safeguard measures, and organize regular emergency drills. In case of vehicle failure or safety accident during the operation of self-driving cars, self-driving transport operators should start emergency response according to the requirements of emergency plan and make emergency treatment; In case of casualties in production safety accidents, it should be reported to the competent department of transportation in time in accordance with the relevant provisions of the state.

Eight, supervision and management

(1) Daily supervision.

The competent department of transportation shall, jointly with relevant departments, strengthen the supervision and management of self-driving automobile transportation business activities, carry out supervision and inspection in accordance with the requirements of "double randomness and openness", and set their functions and powers according to law to urge self-driving automobile production enterprises and self-driving transportation operators to carry out road transportation business activities in strict accordance with relevant national laws and regulations to ensure transportation safety. Local transportation authorities may formulate safety requirements and measures higher than these guidelines in light of local conditions.

(2) rectification of hidden dangers.

If there are major safety hazards in using self-driving cars to engage in road transport business activities, the transportation authorities at the place of operation shall, jointly with relevant departments, determine their functions and powers according to law and order self-driving car manufacturers and self-driving transport operators to make rapid rectification. If transportation safety cannot be guaranteed, it shall be dealt with according to laws and regulations such as the Law of People’s Republic of China (PRC) on Safety in Production, the Law of the People’s Republic of China on Road Traffic Safety and the Regulations of the People’s Republic of China on Road Transportation.

(3) Information feedback.

If there are technical defects, hidden dangers and problems in the operation of self-driving cars, the self-driving transport operators should give feedback to the relevant competent departments in accordance with the law, and the relevant competent departments should urge the automobile production enterprises to quickly investigate and rectify, eliminate potential safety hazards in time and ensure production safety. The transportation authorities in the place of operation should regularly monitor and summarize the local autonomous driving operation services and master the industry safety and operation services. Provincial transportation authorities should report to the Ministry before the end of each year on the operation of self-driving automobile transportation within their respective jurisdictions.

For South Korea？ China clarifies its position on rectifying the chaos in entertainment circles and ＂rice circles＂

CCTV News:Recently, the China Municipal Government launched a series of special actions to rectify the chaos in the entertainment circle and the "rice circle", and some artists, including Korean artists, were shut down in their fan base social accounts. South Korean media are concerned about this, worried that cultural exchanges between China and South Korea will be affected, and even think that China’s relevant measures have a side against South Korea. In this regard, the spokesman of the China Embassy in South Korea introduced the relevant situation and clarified China’s position.

The spokesman said that in recent days, there have been frequent incidents of unethical and anomie such as tax evasion, pornography and drug-related activities among entertainment stars in China. If a famous foreign singer was arrested by the police on suspicion of rape, an actor’s repeated visits to the Yasukuni Shrine were boycotted by the people of China. At the same time, the problem of Internet "rice circle" in China has become increasingly prominent. Various fan groups abuse and slander each other, engage in malicious marketing, and induce and even force fans, including minors, to raise funds to help. In order to brush tickets for idols, some fans do not hesitate to purchase boxes of yogurt, and then dump the yogurt after scanning the QR code on the bottle cap. These behaviors spread a lot of harmful information to the society, which has a huge negative impact on the fans’ consumption groups, mainly young people, and some even violate the law, which seriously hinders the healthy development of the entertainment industry.

In view of the above situation, the relevant departments in China urgently issued a ban and punishment regulations to regulate the management of celebrity artists’ traffic fraud and induce fans’ consumption, and launched the 2021 "Clear Lang" series of special actions, focusing on rectifying the abnormal culture of entertainment circles and "rice circles". The more stars in the spotlight, the better they should set an example, giving the society integrity and giving young people real example power. All the actions taken by the Chinese side are against public order, good customs, laws and regulations, and will not affect China’s normal exchanges with any country.

China and South Korea have learned from each other for thousands of years, forming a profound historical and cultural bond. This year marks the start of the Year of Cultural Exchange between China and South Korea, and next year marks the 30th anniversary of the establishment of diplomatic relations between China and South Korea. Further strengthening China-ROK friendly cooperation conforms to the current situation, people’s hearts and the fundamental interests of both sides. We are willing to continue to strengthen cultural exchanges with the ROK, encourage cultural exchanges and cooperation full of positive energy, and resist vulgar and bad induction and comparison. At present, the activities of the "China-Korea Cultural Exchange Year" are being carried out in a colorful way. We expect cultural exchange to become an inexhaustible motive force to promote the vigorous development of China-ROK relations in the new era and play an active role in helping the development of bilateral relations and promoting the communication between the people.

Clear fingerprints of more than 2,000 years ago were found on the ＂supine figurines＂ of Qin Shihuang’s mausoleum, which was analyzed by Hangzhou criminal investigation experts.

Time goes back to more than 2200 years ago, at the foot of Mount Li in the Qin Dynasty.

Hundreds of thousands of craftsmen, like surging ant colonies, are busy with the huge Mausoleum project. Among the crowd, there is a young man, sweating like a pig, stirring water and loess with his hands, making a group of palace figurines by hand …

This magnificent scene was described by Sima Qian in Historical Records-"The world sent more than 700,000 people to wear three springs, and the copper was poured down … With mercury as a hundred rivers and seas, the machine was instilled, with astronomy on the top and geography on the bottom …"

Among more than 700,000 craftsmen, teenagers are very humble. People from Zhao and Chu? The place of origin is unknown.

After the completion, in order to cover up the truth of the Mausoleum, he failed to escape the fate of being killed. But his works and fingerprints "signature" were left behind, and were finally discovered by today’s archaeologists …

On June 11th, the Cultural and Natural Heritage Day, the Mausoleum Museum of the First Qin Emperor announced the "No.28 figurine" in the hundred-play figurine pit of the Qin Mausoleum for the first time, which attracted a lot of attention and quickly became popular on the Internet.

The 28 th figurine, which has attracted much attention, is called "supine figurine" by archaeologists because of its unique posture.

Many netizens joked, "Is it practicing yoga?"

Khan Lee, director of the Mausoleum Museum of the First Emperor of Qin Dynasty, said, "It belongs to the hundred-play figurines, showing the image of the hundred-play figures in the court of Qin Dynasty. What is special about this figurine is its posture, which may be similar to that of a carp, or it may lean over and lean back. "

Little known is that today, more than 2,200 years later, when it reappeared, there were only 72 pieces and 12 bags of debris, with no head, no hands and lost right leg.

It is quite different from the Terracotta Warriors and Horses. It is speculated by academic circles that these terracotta warriors and horses are hundred-drama warriors and horses that provide hundreds of performances for the court of Qin Dynasty, so the burial pit is tentatively named "Hundred-drama Warrior Pit".

After more than 9 months, the restored figurine is 154 cm long and weighs 101.4 kg. Because of the long time, its body color has been broken and transformed.

Hangzhou criminal investigation expert:

Fingerprints are more in line with the characteristics of young people

"According to Zhou Ping, vice president of the Mausoleum Museum of the First Qin Emperor, three continuous fingerprint marks were found on the painted surface of the abdomen during the protection and restoration of the supine figurines. Experts from dactylography, a professional appraisal institution, collected data and made professional analysis on three fingerprints. After comparison, these three fingerprints are highly similar to those of teenagers, and the craftsman of this pottery figurine should be a teenager. " -According to Xinhua News Agency,

Why can you tell your age from fingerprints?

This fingerprint also aroused the interest of criminal investigation experts of Hangzhou Public Security Bureau.

Police officer Shi Taoning is a senior expert in fingerprint inspection and identification. After carefully studying the fingerprint photos of "supine figurines", he told reporters that "the conclusion of the cultural protection department should be comprehensively judged according to the fingerprint shape, including the overall shape and details."

"If it were me, I would judge from this aspect: a person’s fingerprint is called a ridge, and a furrow is called between two stripe lines. The fingerprints found by Qin terracotta warriors, this furrow is still quite obvious.

"The gap between lines and furrows of young people is relatively large, and the gap between heights of older people is relatively small. Young people are relatively full and elastic, and it is easier to leave obvious details. However, for older people, with the loss of body water, the skin is cracked and shriveled, and the skin friction is damaged after labor, so the lines will not be so clear.

"Found on the terracotta warriors this time, it should be a three-dimensional fingerprint. The furrows and ridges of the fingerprint have a proper width ratio, which shows that they have not been excessively squeezed, which is more in line with the characteristics of young people. Combining these characteristics of fingerprints, we can judge the approximate age.

"Fingerprints are this rule with age, but fingerprint features are basically unchanged for life, except for injuries or big wear and tear. From the morphological analysis alone, it is more in line with the characteristics of young people.

"In addition, considering the average life expectancy of the people in the Qin Dynasty and the fact that they were engaged in manual labor, it makes sense to analyze whether it is left over by young people."

Fingerprints have been found on Qin terracotta warriors many times.

In fact, such mysterious fingerprints have been found on Qin terracotta warriors many times.

Ma Yu, a cultural relic restorer in the Mausoleum Museum of the First Qin Emperor, has participated in the restoration of horse figurines at various stages.

When cleaning a piece of pottery, he found many fingerprints on the piece of pottery, so he used silicone rubber to turn over the mold and take photos to save them.

He said, "This is a dialogue between us and the ancients."

Zhao Zhen, a cultural relic photographer in the Mausoleum Museum of the First Qin Emperor, once photographed nearly 8,000 terracotta warriors and horses. Speaking of finding the craftsman’s fingerprints on the face of the Terracotta Warriors, he was so excited that he choked.

"Clapping one day, I looked up and saw fingerprints on the face of a statue of terracotta warriors and horses, which were left by craftsmen who made terracotta warriors and horses more than 2200 years ago!

"When I saw that scene, time had disappeared, in the same place, he had just left, and I stepped on his footprints …"

The oldest fingerprints come from more than 7000 years ago.

Maybe it was left by a little girl.

The earliest fingerprint found on cultural relics is Yangshao culture more than 7000 years ago, which may have been left by a little girl.

On October 31, 2018, Yang Shuanchao, a researcher at Yangshao Culture Research Center of China Academy of Social Sciences and deputy director of Yangshao Culture Museum in Mianchi County, suddenly noticed a pottery jar fragment in the pit near the ash pit of the site. There is a complete and clear fingerprint on the round and delicate ear of the pottery jar.

The fingerprint experts in the criminal investigation department studied the fingerprints on the fragments: this fingerprint is not only clear, but also very slim. Judging from the size and grain depth, its owner should be a little girl.

The size and weight of the pottery jar itself are not too big, so it is very possible to finish it by a little girl.

In the primitive society with extremely underdeveloped productive forces, every labor force is very precious.

Cultural protection experts infer that in the age of eating and drinking blood, our ancestors took part in labor when they were children.

In addition, experts also found a problem: there are a lot of sweat holes in the fingerprint left by the little girl, and the number of sweat holes in animals depends entirely on the individual’s exercise. Therefore, it is judged that the little girl is engaged in a huge amount of labor and her body is always in a state of exhaustion.

Police officer Shi Taoning believes that it is actually very difficult to judge the sex of men and women from fingerprints.

"Generally speaking, male lines are thicker than female lines, but they are not absolute.

"In fact, the age of fingerprint speculation is itself based on the universal characteristics of high probability of fingerprint morphology, and it is not 100% accurate. To make an analytical conclusion, we must also make a comprehensive judgment based on multiple information of the actual situation. "

As for "Yangshao Fingerprint", Liu Pingping, a famous fingerprint scientist and deputy director of the Fingerprint Inspection Committee of China Criminal Science Association, believes that "fingerprints and fingerprints have been widely used in this era (Yangshao culture), and’ beauty by finger’ has become a fashion, and’ faith by finger’ has dawned, which has opened a precedent for human fingerprint application."

Like the little girl in Yangshao more than 7,000 years ago, the teenagers at the foot of Lishan Mountain more than 2,000 years ago had the same humble and short fate, and were not even qualified to leave their names on their works.

"Inadvertently", he quietly pressed three fingers on the terracotta warriors.

Follow the finger as the letter! After more than 2,000 years, I implicitly told people today, "I have been here …"

What clothes are the hundred-play figurines wearing?

Hangzhou has produced the latest research results.

At present, the Mausoleum Museum of the First Qin Emperor is cooperating with the China Silk Museum to study the costume restoration of No.4 Baixi figurines in Baixi Pit.

On June 22nd, at the Silk Road Cultural Protection Science and Technology Forum held in Hangzhou, Zhou Yang, deputy director of the China Silk Museum, showed the latest achievements in the research on the restoration of the costumes of hundreds of opera figurines in the Qin Dynasty-purple brocade fabric with black octagonal patterns and yellow dots …

Museum experts who participated in the restoration project told reporters that this hundred-play figurine to be restored has rich clothing patterns, including at least three patterns: geometric pattern, octagonal star pattern and cloud pattern.

Restoring Decorations of No.4 Servant of Baixi Figurines

More than 2,200 years ago, the "hundred operas" artists of the Qin Dynasty, such as the "supine figurines", probably wore such clothes and performed acrobatics and dances for Qin Shihuang and other officials …

Original title: "Clear fingerprints found more than 2,000 years ago on the" supine figurines "of Qin Shihuang Mausoleum! Hangzhou criminal investigation expert analysis: how to judge that the manufacturer is a young craftsman from fingerprints? 》

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Beijing will heat up the heating system in advance to store heat and strengthen the operation regulation in the snowfall and cooling weather.

　　BEIJING, Beijing, December 10 (Reporter Xu Jing) According to the forecast of the Beijing Meteorological Department, there will be snowfall and cooling weather in Beijing in the near future. In order to do a good job in ensuring urban operation services, the Beijing Municipal Urban Management Committee made arrangements in advance, strengthened the regulation of heating systems, and deployed snow sweeping and ice shoveling to ensure the citizens’ warm winter and safe travel.

　　The Committee issued an early warning notice to ensure the heating service. Refine the implementation of the safeguard plan and take countermeasures in advance. All districts and heating enterprises are required to pay close attention to the meteorological conditions in their regions, strengthen risk early warning and judgment, raise the temperature and store heat in advance, and do a good job in operation adjustment on the premise of ensuring the safety of heating operation. Especially in outer suburbs, old residential areas, low-temperature areas and other special areas, targeted measures should be taken, fully combined with online room temperature monitoring and user characteristics, fine regulation and control should be carried out, and the balance of hydraulic conditions should be continuously optimized to provide strong heating guarantee.

　　At the same time, the Committee strengthened operation monitoring to ensure the safe operation of the system. All districts and heating enterprises are required to strengthen the operation monitoring of weak links and potential risks in the heating system during the cooling period, do a good job in the investigation and rectification of potential safety hazards of heating equipment and facilities, and take anti-freezing measures in advance to ensure the safe operation of the heating system. Strictly implement the 24-hour duty system, rationally allocate operation and maintenance personnel, implement emergency material reserves, and properly handle emergencies.

　　In addition, the Committee has strengthened inspections and done a good job of receiving complaints. All districts are required to actively organize and carry out the "four noes and two straights" inspection, and assign special personnel to keep an eye on the key and difficult problems found in the inspection, and sort them out and include them in the list of "winter disease and summer treatment" plans; It is necessary to pay close attention to the communities and key users who have concentrated on historical appeals in a timely manner, do a good job of handling complaints immediately, give full play to the role of the "heating housekeeper" service model, actively carry out the "visiting the people to ask for warmth" activities, and improve the quality of heating services.

　　It is understood that in accordance with the "Beijing Emergency Plan for Snow Sweeping and Ice Shoveling (2023)", Beijing has launched a blue warning response for snow sweeping and ice shoveling. The Beijing Municipal Urban Management Committee organized all districts and operating units to hold deployment meetings, arranged all snow sweeping and ice shoveling work in advance, and defined the responsible areas and sections of snow sweeping and ice shoveling work. (End)

Self-reliance is the last word. Putin gives a tough answer to Russia-US relations.

　　On May 7, Putin was sworn in as President of the Russian Federation for the fourth time. This has brought Russia-US relations at the freezing point into the era of "Putin 4.0". Economic sanctions, military containment, and regional games have become an unavoidable whirlpool in Russia-US relations. Some analysts said that in the short to medium term, Russia-US relations are hard to surprise and may even continue to deteriorate.

　　The next six years will be a great test for Putin and Russia in charge. Can this big ship named "Russia", with Putin at the helm, break the ice between Russia and the United States and realize the rhetoric of "give me 20 years and return you a strong Russia"? Putin gave a tough guy’s answer: now Russia is like a phoenix reborn from nirvana. Nothing will prevent Russia from determining its own future, and no one can stop the "Russian" ship from moving forward. Self-reliance is the last word.

　　Moscow, May 7, 2018, Russian President Vladimir Putin speaks at the inauguration ceremony held in Moscow Kremlin.

　　In the face of the US "sanctions storm", Russia concentrates on practicing its internal strength and regards economic development as its core driving force.

　　Since the Ukrainian crisis in 2014, the United States and Europe have successively imposed economic sanctions on Russia. Especially since US President Trump took office in 2017, he has set off a series of "sanctions storms" against Russia. Western sanctions have made the external environment for Russia to achieve its own development and breakthrough more and more severe.

　　Under the circumstance that "sanctions" seem to have become the background color of Russia’s relations with the United States and Europe, how Russia uses its existing resource advantages to solve the most urgent internal development problems is a major problem that Putin will continue to solve in his new term. At present, although the Russian economy has improved slightly, it still faces great challenges.

　　In his inaugural speech, Putin pointed out that it is necessary to develop the economy, pay attention to internal affairs and people’s livelihood, and honor pre-election promises. For example, to implement reform measures, activate economic vitality and achieve economic and technological breakthroughs, especially to enhance Russia’s competitiveness in key areas, increase investment in infrastructure construction, accelerate the introduction of digital technology, promote urban and rural modernization, and improve social welfare.

　　Alexei Mu Xin, director of the Russian Political Information Center, believes that the conflict between Russia and the United States is an economic conflict, not a war conflict, and both sides have suffered certain losses. He said that since the Ukrainian crisis, the United States has used sanctions to try to launch an economic "blitzkrieg" against Russia, expecting Russia to be soft under sanctions and comprehensive pressure and accept American conditions. Facts have proved that the American attempt has failed.

　　In response to the US military containment, Russia "shows muscles" strongly, but it has not given up the dialogue channel.

　　Almost at the same time that Putin began his fourth presidential term, US Naval Operations Secretary John Richardson said on the 4th that he would restart the US Navy’s Second Fleet, which was dissolved in 2011, in order to curb the expansion of Russian maritime power and deal with Russia’s security threats.

　　In fact, Russia’s military ability to resist foreign aggression is relatively strong. It has more resources to exert its military power and arouse the fear of the other side than to confront the United States and Europe economically and diplomatically, and it is relatively easy.

　　Putin’s State of the Union address this year showed a series of Russian latest military scientific and technological achievements in a long space, which not only shocked the United States, but also shouted to western countries that its economic sanctions and military containment against Russia "didn’t work".

　　Curtov, editor-in-chief of Russia’s National Strategic Issues magazine, said that in view of the fact that the United States regards Russia as its main strategic competitor, its policy toward Russia is becoming increasingly tough, and it is engaged in political and military confrontation with Russia, as well as the development of the situation in Syria, in order to cope with this situation, Russia may spend huge sums of money on national defense. Curtov said that although Russia has made great achievements in the fields of aviation, space and weapons, it has not developed enough in the fields of electronic information, which makes it impossible for Russia to win quickly and with little damage in the face of military conflicts. Moreover, in the short to medium term, such conflicts between Russia and the United States will continue.

　　In 2010, Russia and the United States signed a new version of the Treaty on the Reduction and Limitation of Strategic Offensive Arms, which set a new upper limit for the strategic nuclear weapons of the two countries. The treaty came into force in February of the following year and is valid for 10 years. Mu Xin believes that the further development of the Russian-American conflict may lead to the failure of the negotiations on updating this treaty.

　　Russia is also actively seeking dialogue in the face of the US’s artificial hostility towards Russia. Russian Foreign Minister Lavrov said on May 3, 2018 that if the United States can match its words and deeds on some issues, then Russia is willing to negotiate with the United States on the arms race and other global challenges.

　　In regional conflicts and great power games, Russia has actively carried out multilateral diplomacy and demonstrated its geopolitical ambitions.

　　In recent years, the practice of international affairs has proved that the handling or solution of some international problems cannot be separated from Russia’s active participation. Washington post said that Putin’s foreign policy reflected the rising geopolitical ambition of Russia. In addition, according to the latest poll released by Russia on the 7th, most Russian citizens believe that Putin’s main achievement is to restore Russia’s status as a great power.

　　Mu Xin believes that despite the constant regional game between Russia and the United States, Russia-US relations are unlikely to change in the short term, but Russia has made significant changes in other diplomatic directions and actively enhanced its influence. In Europe, Russia will work closely with some European countries including Germany. He believes that different from the attitude of most NATO members towards Russia, some European countries prefer a moderate policy of "looking north", so Russia will resume and strengthen contacts with these countries.

　　In the Middle East, Russia may strengthen its ties with Israel. As an important participant in Middle East affairs, and with the help of close cooperation with Iran, Russia can play a role as a link between Iran and Israel. Around the conflict between the Iranian nuclear deal and the United States, Israel and Iran, Russia can mediate and avoid the escalation of the conflict between the two sides.

　　In East Asia, Russia will further strengthen cooperation with China. At the same time, strengthen contacts and business contacts with Japan, South Korea and Vietnam. Relations with India and Indonesia are also an important part of Russia’s Asian policy, and strengthening cooperation with eastern countries may be one of the characteristics of Russia’s foreign policy in the next few years.

　　The next six years will not be easy for Putin and his team. However, as Putin emphasized, a difficult test is a springboard and a brand-new starting point for Russia’s development.

　　(Compilation: Wang Yinuo’s written materials come from: Xinhuanet, People’s Daily, Reference News, Global Times, Zhongxin.com, Overseas Network, etc.)

Android’s strongest productivity tool! Vivo Pad3 Pro get started

Why do you want to buy a tablet? The tablet is the third screen between the mobile phone and the PC, taking into account the advantages of both. Business trip can easily replace notebook office, review materials at the end of the term, take notes, play games and watch movies on the big screen.

Today, I will bring you a comprehensive evaluation of vivo Pad3 Pro, and see if the new vivo tablet, which combines a 13-inch 3.1K resolution giant screen, a 11500mAh battery, a flagship chip of Tianzhu 9300, an office suite that is interoperable on all platforms, and a blue heart model, can play the flagship role.

13-inch 3.1K giant screen and eight speakers, shocking audio-visual experience.

Vivo Pad3 Pro uses a 13-inch 3.1K resolution display.3:2 golden screen ratio and high refresh rate of 144Hz,It ensures that both delicate text reading and dynamic video playback can provide an unparalleled visual experience.

Android's strongest productivity tool! Vivo Pad3 Pro get started

The peak brightness of 900nit and P3 wide color gamut coverage make the colors more vivid, and support HDR dual-engine technology, which further improves the contrast and layering of the picture.

Such a display effect can ensure users to enjoy clear and bright images, whether indoors or outdoors.

Android's strongest productivity tool! Vivo Pad3 Pro get started

In terms of speakers, vivo Pad3 Pro adopts an audio-level eight-speaker combination of 4 bass units and 4 treble units, which makes it more immersive when watching movies.

Vivo Pad3Pro adopts the "de-crosstalk" sound field widening algorithm, bid farewell to the constraints of headphones, and can also get a spatial audio experience through speakers. Aiming at the peaceful elite and other games, the directional amplification of the sound volume can realize the position identification.

Blue Crystal X Tianji 9300+11500mAh, with strong performance and lasting battery life.

Vivo Pad3Pro is equipped with Blue Crystal X Tianji 9300+LPDDR5X memory and UFS4.0 flash memory.Tianji 9300 is one of the latest flagship chips in the Android market.Its powerful performance needs no elaboration by the author.

Android's strongest productivity tool! Vivo Pad3 Pro get started

Maybe you don’t know what sapphire is yet. Technology stack, the blue crystal chip, as the long-term investment technology brands of vivo, represents the control of vivo on chip technology.

This technology will fully tap the potential of Tianji 9300, and make exclusive adjustments in six major tracks: performance, display, battery life, AI, games and communication.

The flagship chip is usually limited by the narrow internal space of the mobile phone and can’t play its due strength. The space of the tablet is large, and the strength of the flagship chip is completely released.

Not only that, vivo Pad3 Pro also has a high thermal conductivity copper cooling matrix, 37000mm? After all this talk, what is the actual performance of the three-dimensional cooling system with high-power graphite cooling blessing?

Android's strongest productivity tool! Vivo Pad3 Pro get started

In the latest version, the running score of the safety and immunity has reached 2.08 million, which is the TOP level in the current processor.

For the test of game performance, we chose the popular games Genshin Impact and Star Dome Railway to test the frame rate.

During the test, we adjusted the brightness of the screen to automatic brightness, and the test environment was room temperature of 24℃, and set the game quality and frame rate to the highest level.

Android's strongest productivity tool! Vivo Pad3 Pro get started
Half an hour "Star Iron"

Android's strongest productivity tool! Vivo Pad3 Pro get started
Half an hour, Genshin Impact

Android's strongest productivity tool! Vivo Pad3 Pro get started

Genshin Impact and "Star Dome Railway" have a resolution of nearly 1400P, and the whole process runs in 60 frames, and the highest temperature of the back shell is only 35 degrees Celsius. It can be said that vivo Pad3 Pro is the most powerful Android tablet at present.

In addition to these, the vivo Pad3 Pro is also equipped with the largest battery of the current mainstream Android tablet: 11500mAh, which is very scary after the measured battery life.

Under automatic brightness, 8 hours of work time, watching movies online all the time, 50% left after work, which means that watching movies can be used for about 16 hours.

What surprised me the most was the horrible standby ability of vivo Pad3 Pro. I went to work and tested the Genshin Impact frame rate, but I didn’t quit the game screen. The next morning, I found that the battery didn’t drop.

This is because vivo Pad3Pro is equipped with pure background technology, which rewrites the Android kernel, lightens the system and the three-party application background, avoids stealing tasks and unnecessary refreshing in the background, only wakes up the necessary services of users, and adopts "smart sleep" technology to improve the off-screen resource scheduling, which can achieve 70 days of long standby.

In terms of charging, vivo Pad3 Pro is equipped with a 66W fast charge. Let’s take a look at the actual measurement.

Android's strongest productivity tool! Vivo Pad3 Pro get started

After charging for half an hour, the power reached 34%, and it was fully charged in about one and a half hours, and the whole charging power was stable.

Blue heart model +OriginOS4, office comparable to PC.

The productivity attribute of flat panel is one of the reasons why many people place orders. The addition of large model makes the productivity of flat panel go up a step. The blue heart V released last year was finally put into vivo Pad3 Pro.

Blue Heart V has five outstanding functions, which are related to "super semantic search, super question answering system, super writing ability, innovative image generation and deep intelligent interaction" and so on.

First of all, its super semantic search technology is equivalent to an advanced fuzzy search method. Users do not need to input keywords accurately.

Just describe relevant information, such as mentioning "photos taken last summer" or asking "recently saved documents", and Blue Heart V can quickly locate and present relevant photos or files according to these descriptions.

This function is particularly efficient when dealing with a large number of pictures, which not only helps users find specific photos quickly, but also can be used to retrieve special types of pictures such as invoices.

Android's strongest productivity tool! Vivo Pad3 Pro get started

Secondly, the Super Q&A module not only provides a wide range of question answering services comparable to ChatGPT, but also strengthens the humanized content refining function.

In the face of long articles, Blue Heart V can refine and summarize based on web pages, documents or links, and support in-depth question-and-answer interaction within the text.

Android's strongest productivity tool! Vivo Pad3 Pro get started

Furthermore, super writing ability means that Blue Heart Small V can create different styles of text content according to users’ customized needs. What’s more impressive is that it can also generate mind maps of corresponding themes synchronously, providing users with the overall framework and preliminary ideas of project conception.

In addition, the super-drawing function is both practical and interesting. It can not only automatically generate pictures containing the required elements according to the user’s instructions, but also realize a series of automatic matting and editing operations, which greatly simplifies the picture processing flow and is more convenient and efficient than manual adjustment.

Android's strongest productivity tool! Vivo Pad3 Pro get started

Finally, the super intelligent interaction is to seamlessly connect the intelligent experience into various applications and operation details of the mobile phone by integrating into the OriginOS4 operating system, such as providing functions such as big-bang information extraction and accurate matting inside the application. Although these seemingly small function points are actually supported by powerful computing power.

In short, the interaction with Blue Heart V is extremely convenient, whether through the sidebar, floating icon or atomic component, it can be easily called out and communicated with it. There are many ways of communication, including text input, voice dialogue, and even dragging voice clips and documents directly.

Let’s take a look at the exclusive killer level function of vivo — — Vivo office suite.

This time, the vivo office suite ushered in a new upgrade, which was born for cross-device collaboration. You can use the tablet to remotely control the computer, you can also use the tablet to continue the unfinished writing on the Mac, and even you can drag and drop files across devices on your mobile phone, tablet and computer with just one mouse.

Vivo Pad3 Pro also supports remote control of Mac computers, and supports remote control of computers to complete document editing, application operation, computer shutdown and restart.

Android's strongest productivity tool! Vivo Pad3 Pro get started

In addition, vivo Pad3Pro has a built-in NFC portal, so you can easily view and access photos and files of your mobile phone across the screen in your photo album and file management App, and even the mobile phone interface can be projected to the tablet by just touching the upper right corner with your mobile phone.

Enrich accessories, and expand the usage scenarios of tablet computers.

For office productivity, a tablet is not enough. vivo Pad3Pro is equipped with a smart touch keyboard 3 Pro.

This keyboard adopts the configuration of 1.5mm keystrokes, 18mm keystrokes and 15mmx15mm keycaps, with strong typing resilience and spacious layout, which is consistent with the notebook experience.

Android's strongest productivity tool! Vivo Pad3 Pro get started

On the basis of supporting Windows and Mac dual-system shortcut keys, common function shortcut keys are added, such as keeping independent ESC key and backspace key, increasing global and regional quick screen shots, and supporting custom App-related shortcut keys, such as starting the original god with one click. And 6527mm? Oversized touchpad, which supports free manipulation of multiple gestures.

Android's strongest productivity tool! Vivo Pad3 Pro get started

The intelligent touch keyboard can also be a bracket, which supports 0 ~ 140 degree stepless support.

Android's strongest productivity tool! Vivo Pad3 Pro get started

The most praise is that the tablet supports keyboard mapping, and even adapts to some common games. With the mouse, you can completely play Android games with the keyboard and mouse.

Android's strongest productivity tool! Vivo Pad3 Pro get started

Of course, there is a matching stylus — — VivoPencil2, which has ultra-low time delay and 4096-level pressure sensing, can make the pen mark follow the nib without delay and follow the hand smoothly.

finally

On the whole, vivo Pad3Pro has no slots, and the top hardware level at the same price, especially equipped with Tianji 9300, the top processor in Android, ensures smooth AI operation and multitasking.

And the display, performance and endurance performance are excellent, and it is equipped with innovative blue heart model and OriginOS4 system, which gives the tablet strong productivity and convenient operation experience.

Android's strongest productivity tool! Vivo Pad3 Pro get started

It can be seen that vivo has polished the tablet for three generations and spent a lot of thought on the details. The big model just released is integrated into the office section, and the supporting keyboard not only makes more custom buttons, but also supports the mapping of game buttons, taking into account both office and entertainment.

Obviously, vivo thinks about what kind of tablet consumers want, not only the software ecology of Android, but also the light office ability of Windows and Mac, and also the interoperability of mobile computer tablets. This time vivo Pad3 Pro did it.

30 years after foreign pharmaceutical companies entered China, Lilly, Pfizer and Merck’s new ways of playing.

This article comes from WeChat WeChat official account:Deep blue view (id: mic-sh 366), Author: Gao Yi, editor: Wang Chen, head picture from: vision china.

In May, 2023, with the latest data of the most Alzheimer’s disease drug from Lilly, this century-old pharmaceutical company continued to sound the upward horn, and its market value climbed to the $400 billion mark, becoming the most valuable pure drug enterprise in history.

When the stories in the field of cancer were exhausted, the investors on Wall Street found the track of "losing weight" and continued to write the myth that the pharmaceutical industry will always go up, which also contributed to the market value growth of Novo Nordisk and Lilly this year. Years of hard work in the CNS field has added a icing on the cake to Lilly.

However, Lilly global is flourishing, and the voice of Lilly China seems to be getting smaller and smaller this year.

Lilly’s last big event in China was the 2022 new medical insurance catalogue at the beginning of this year. Four new products/indications successfully entered medical insurance, including two cooperative products from Cinda. In the past year, the only pipeline renewal that can be seen in China, one is RET inhibitor and the other is a hair loss product, which obviously goes against the thickness of Lilly global’s powerful product pipeline.

Photo: Lilly’s Q1 product performance in 2023.

Source: official website, Jibao finishing

From the time point of view, Lilly is one of the first batch of big manufacturers to bet on China. As early as 2012, Lilly moved its R&D center to China, trying to speed up the listing of global products in China. However, the R&D center in China District opened early and closed early. Perhaps it is the long-term single-digit income ratio in China District, which makes this MNC factory unwilling to invest more energy in cultivation;The rise of local enterprises in these years has also had some run-on effects on foreign enterprises to some extent. In 2022, Lilly’s China business contracted to 1.453 billion US dollars, down by 10 percentage points.(Source: Huachuang Securities).

More than courtesy, under the double pressure of competition between VBP and local enterprises in the past two years, the domestic business of multinational giants has shrunk. One is that the speed of introducing products from foreign companies is slower than in previous years, and the other is that the demand for talents is becoming more and more Buddhist.

A headhunter said that since the second half of last year, the recruitment needs of foreign pharmaceutical companies in all functions, whether business or clinical, have declined; Some non-business core positions that were quite popular a few years ago(such as "digital innovation", etc.)In the past two years, it has almost disappeared completely.

The basic executive positions such as medical representatives were originally the most mobile, but the post pattern has not changed much in the past two years. A person who pays attention to this kind of market mentioned that this is related to the slow iteration of new products in the past two years. Even if new products are listed, they are basically handed over to the original team to do it together. For example, BMS set up a separate team for PD-1 in 2018, which has not been seen in the last two years.

However, although Lilly’s pharmaceutical business in China is operated by Buddhism, it does not prevent Lilly from embracing the rapid growth of this emerging domestic market in other ways. For example, Lilly cooperates with Hutchison and Cinda to help them bring their products to the market, even to Europe and America, and use the resources of their own big factories to earn a share of the money; Another example is LAV, which is synonymous with the success of domestic biomedical first-level investment.

Neither the introduction/authorized cooperation nor the next incubation is exclusive to Lilly. Other multinational pharmaceutical companies have been running in China for nearly 30 years, and now they are slowly adapting to the ever-changing new market with some comfortable postures.

First, "retreat to the high-end route"

In January, 2023, the annual meeting of Huizhi, which was formed by the merger of Pfizer’s mature business units Puqiang and Mylan, was held in Macau, with an exceptionally grand scale.

Behind the luxury annual meeting is its solid growth. According to a participant, Huizhi’s in-hospital sales data this year is obviously better than expected, and the business authorities dare not talk about the specific figures too high-profile, but only give a growth curve that looks obviously upward. Last year’s Huizhi, the bonuses of the sales teams were also exceptionally good.

The number of hospital growth data of Huizhi China is unknown, but from the financial report of Huizhi last year, Greater China was in Q4 last year.(after the epidemic)Year-on-year growth reached 10%. Last year, China earned 2.201 billion US dollars, making it the only market with positive year-on-year growth in net profit.

The main driver of the growth of Huizhi China is Lipitor.(atorvastatin)Luo huoxi(amlodipine)And Xanax(Alprazolam)Among them, the first two were included in the national procurement catalogue long ago. This makes the whole market rethink a question:Is volume a good business after all?

Although the head foreign companies represented by Pfizer and AstraZeneca have launched a series of "grassroots" movements in the past few years, in 2021, Pfizer’s grassroots team reached 600 people, and AstraZeneca’s county team reached a maximum of 4,500 people.

At first, everyone’s idea was to be in a vast market with a super large base. Every 1 percentage point increase in penetration rate is a big increase in the overall scale. However, the following nationwide procurement with quantity not only greatly reduced the profit margin of drugs, but also introduced a large number of "barefoot" players who had never paved the way for the market, which made the "grass-roots strategy" of these large foreign companies a decoration.

Considering the welfare and per capita output, the sales efficiency of foreign pharmaceutical companies is inherently inferior to that of local players, so they can only "retreat" to the high-end market.

Of course, choosing a "high-end market" also requires selective capital. "High-end" doesn’t really mean that products are much higher than competitors in quality and clinical data, but more is a process of brand and doctor-patient psychological cognition, which is inseparable from the long-term market education made by these big manufacturers and the dozens of academic forums that have been smashed in the past decade.

Therefore, sales is not a simple "department meeting" and a dinner party. Whether it is a foreign pharmaceutical company or a local rising star, if you really value your products, the work of the marketing department is indispensable. It should be pointed out that this budget often needs to be integrated into the pricing of a drug.

Both centralized purchasing and medical insurance negotiation can solve the problem of "accessibility" to a certain extent, but the effective use of drugs also needs the promotion of pharmaceutical companies themselves.

Back to Pfizer’s business in China, as long as this "high-end" strategy can still operate normally at present, new products from global will be continuously injected and then profits will be contributed to the world.

This kind of "China agent of multinational pharmaceutical companies" business is also the most classic and good game for foreign pharmaceutical companies. Pfizer is doing it, and Takeda, Novartis, GSK and so on are basically following this strategy at present.

When the global products of these multinational pharmaceutical companies are not strong enough, these companies will also make some deeper attempts in China.

Second, BD cooperates to make a fire by the stove.

Among them, the most representative belongs to Merck.

Although the ceiling of tumor immunotherapy and drug K have now become the proper "drug king", Merck has actually had nothing to do with the treatment field of tumor for a long time.

Merck secured the TOP5 position in the world with simvastatin and losartan. Since then, it has been supported by two major categories: anti-infection and vaccine, and has made heavy income in several sub-sectors such as AIDS, hepatitis C and HPV. Therefore, even in the early 21st century, Roche’s three monoclonal antibodies have already begun to take shape, but the proud Merck seems to have no need to know what antibody drugs are, so he met Schering-Plough.(K medicine source prescription)Before, there were almost no macromolecular products in Merck’s laboratory.

In the second decade, biopharmaceuticals slowly moved to the center of the stage. Half of the TOP10 best-selling products in the world were protein drugs, and Merck himself tasted the sweetness of K drugs. However, the cultivation cycle of biomedical technology needs to be calculated in ten years. It is not easy for Merck, which lacks macromolecular genes, to come up with a mature antibody drug platform to adapt to the pipeline development of such a billion-dollar giant in a short time.

So,When ADC took over the immune products and went to the foreground, Merck, who couldn’t wait, had to put down his body and seek external cooperation.

Therefore, Merck found Seagen, the "originator of ADC", because of his great family business. However, Seagen, whose price has been difficult to negotiate, ended up with Pfizer, which paid an extra $12 billion directly to intercept Hu Merck.

Merck, on the other hand, had to focus on Collen, an old friend of China, and directly won nine ADC molecules in one breath, which was less than a quarter of Seagen’s acquisition even if all the total package prices were included. Merck’s deal could not be said to be uneconomical.

In May this year, Ms. Ji Juan, the head of Merck’s business development and authorization in Greater China, mentioned at the third Sequoia Global Medical and Health Industry Summit: "Merck’s product introduction is distributed in various treatment fields, clinical stages and different mechanisms." Merck will not only focus on one or two big therapeutic fields now, as long as things are good, it can be digested. To some extent, it also reflects the comprehensiveness of large factories.

Merck’s eclectic products contributed half of the company’s revenue last year. If the ADC field continues to deepen and become more and more accepted by the global market, a considerable part of Merck’s tens of billions of dollars in revenue in the future may come from laboratories in China.

With the domestic R&D-clinical capability reaching a higher level, it is not uncommon for China to feed back the world.License out has also become a commonplace topic.But an interesting point is that the number of domestic and foreign authorizations and the total amount of cooperation are increasing, but the down payment is decreasing.

On the one hand, "returns" have become more frequent in the past two years, such as the ADC of Genting Xinyao, the PD-1 of Cinda, and the BTK of Nuocheng Jianhua, which has reduced the certainty of this authorized cooperation;

On the other hand, whether local enterprises or partners, everyone is more willing to seek innovation in the model, and both sides make a concession and take what they need to tell the story more satisfactorily. For example, Cinda and Sanofi, and for example, Merck and Columbine Botai, both of which are mixed with equity transactions.

However, in a mature market, the BD transaction of License in/out itself is a very common thing. The details such as transaction amount, down payment, object and method only reflect the strategic choice of participants at this time node. When the valuation is high, the efficiency of self-research is higher than that of external mergers and acquisitions, and when the industry is deserted, large companies with spare money are more suitable for expansion.(rather than self-research).

The diversification and normalization of BD cooperation shows that the biomedical market in China is slowly maturing.

Third, hatch in person

After the dissolution of AstraZeneca China R&D Center, it became Di Zhe. After running for less than three years, it landed in science and technology innovation board and rose from the bottom of last year, and its share price tripled at the highest. AstraZeneca, as a major shareholder accounting for 26% of the shares, in addition to the premium on financial investment, it can carry out in-depth cooperation on the product pipeline through Dizhe in the future.

More importantly, AstraZeneca can use the business card Dizhe to do some deeper cooperation in finance and project mergers and acquisitions in the future. A typical example is AstraZeneca Zhongjin Medical Industry Fund, which was established with CICC the year before last. It is very comfortable in fundraising and investment, and currently holds 13 medical and medical projects. AstraZeneca’s business in China is increasingly diversified.

In addition to AstraZeneca, Deqi Medicine, which was established in 2016 with the support of Xinji Medicine, a leading global biopharmaceutical company, also has a little "incubation nature".

The founder of Deqi Medicine comes from the R&D executives of Xinji. Half of the main projects come from Xinji, and some of the money from Angel Wheel just landed is given by Xinji. However, considering that Xinji’s share in Deqi was less than 6% at the time of IPO, it was not controlled, but it was an enterprise hatched by Xinji after all.

What can be controlled is called "incubation", and what can’t be controlled can only be called "deep cooperation"In addition to Deqi, another big hand of Xinji is Baekje.

In 2017, Xinji awarded a cooperation with a total amount of US$ 1.393 billion, which not only helped Baekje just listed on the US stock market, but also boosted its prosperity. At the same time, it used its own mature products and the commercialization team of Xinji Company acquired by Baekje in China to promote Baekje to establish a commercialization system.After this cooperation, Baekje was arrogant all the way, and the market value of US stocks almost caught up with Japan’s MNC giant Takeda. However, Xinji itself sold herself to BMS in 2019, and this cooperation was suspended. The "breakup" between Xinji and Baekje may have been doomed.

Amgen replaced Xinji and continued to cooperate with Baekje in depth, which is also "giving money and products". Perhaps it is more optimistic about the potential of this company. Unlike Xinji, Amgen directly turned itself into a major shareholder of Baekje.

It is worth mentioning that nowadays, the cooperation between multinational pharmaceutical companies and local companies is more and more diversified, not limited to one or two ways.

For example, Baekje and Amgen are deeply bound, and Baekje also supports the construction of its tumor pipeline to Novartis License out products, while the latter, while the pipeline is supplemented, can also empower Baekje to commercialize in the world;

Furthermore, AstraZeneca’s cooperation with the local area can be described as "dazzling": green leaf exchange products, binding with Internet channel geeks, introducing the ADC of No.1 and No.3, and introducing the ADC of Connoa/Lepu Bio at the same time … As for other sales and market cooperation, there are countless more.

The reason why foreign companies are more and more willing to play is that the rules of the game are more and more fair.

In the past two decades, a few domestic enterprises have the ability to develop compound technology to meet the differentiated needs of the low-level market that foreign pharmaceutical companies cannot cover. Most so-called pharmaceutical companies only earn coins in the circulation field.

With the improvement of the independent ability of the pharmaceutical industry, the wave of innovation is superimposed. From following imitation to innovation self-sufficiency to "in China for global", the productivity of foreign companies’ products is no longer suppressed, and the policy protection of local pharmaceutical companies is becoming more and more negligible. Everyone is playing together at the same level and conditions.

Behind this is the growing maturity of the entire pharmaceutical industry in China.

Maturity also means that local pharmaceutical companies need to abandon the luck of "home advantage" and come up with 100% strength to compete with these large foreign companies with a history of 100 years.

This article comes from WeChat WeChat official account:Deep blue view (id: mic-sh 366), Author: Gao Yi, Editor: Wang Chen

Introduction of Wuling new SUV models？

The latest masterpiece of Wuling Automobile-Xingchi SUV, with its unique design concept and attractive price positioning, is undoubtedly aimed at the young people’s car market. This SUV model, which is specially designed for young people, is designed to be their ideal choice:

Xingchi SUV continues the "wing aesthetics" style of Wuling silver standard, and the front face adopts an eye-catching matrix grille with polygonal headlights, which exudes a strong sporty atmosphere. The suspended roof, dense rims, eye-catching red brake calipers and diffusers, and the "S" logo on the air intake grille together create a distinctive personality and dynamics.

Stepping into the car of Xingchi, you will find that the interior design with black as the main color is matched with green contrast elements, creating a fashionable space without losing individuality. Exquisite chrome-plated decoration and the application of piano paint panel enhance the quality of the interior. In addition, the 10.25-inch central control panel is equipped with Ling OS Linxi car system, which is full of technology and meets the young people’s pursuit of intelligent driving.

Xingchi provides two power options: 1.5L manual /CVT and 1.5T CVT. For car buyers with sufficient budget, 1.5T CVT power is undoubtedly more popular, with a maximum power of 108kW and a peak torque of 250N·m, providing strong power performance.

Although Wuling Xingchi has attracted a lot of attention because of its appearance and price, in the increasingly fierce market competition, in order to stand out, Xingchi needs to further consider adding young people’s favorite configurations, such as ejection mode and exhaust sound, in order to achieve real differentiated competition.

五菱星驰

Wuling xingchi SUV is actively seizing the market of young people with its unique design, rich configuration and affordable price. However, in order to stand out from many competitors, Xingchi needs to continue to explore and innovate to meet the growing individual needs of young consumers.

Audi’s domestic new car planning was exposed, A6L and Q3 were all redesigned, and S4 Travel Edition came.

In 2022, at least seven new cars will be launched in China, including three domestic models, namely A6L, Q3 and Q4 e-tron, and four imported models, namely A8, e-tron GT, S8L and S4 Avant. Among them, the mid-term redesigned A6L should be one of the most concerned models. The new car will adopt the latest design and the configuration is expected to be adjusted. For consumers who plan to buy a car this year, they may wish to wait and see for a while.

Mid-term change A6L

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According to overseas media reports, the mid-term redesigned A6L is expected to be unveiled in the first quarter, while the domestic mid-term redesigned A6L has also started road test last year and is expected to be listed this year. As a mid-term redesigned model, the exterior details are adjusted, including the front and rear LED light groups and bumper shapes, which are expected to be closer to A8, and the interior of the new car will be consistent with the cash. In terms of power, the mid-term A6L will continue to use 2.0T and 3.0T engines, and the transmission system will be matched with a 7-speed dual-clutch gearbox. Some models will also provide a quattro four-wheel drive system.

Mid-term change Q3 family

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Audi will launch at least seven new cars this year-Figure 3 "src =" https://x0.ifengimg.com/ucms/2022 _ 02/B0748F1EADCB333DFB4 CDD454f9cd697C45F50 _ size48 _ W680 _ H586.jpg ">

The Q3 and Q3 coupes with mid-term changes are undergoing technical transformation, and the new cars are expected to be released and listed this year. In the middle period, the Q3 and Q3 coupes were mainly optimized and adjusted in the front face, interior and other details to further enhance the sporty appearance and luxury interior. The new car will enhance the difference between S-line and Design line, and adjust the highlights of air inlets on both sides, chrome-plated elements, bumpers and door handles. The interior is upgraded with leather covering and stitched. In terms of power, the Q3 family will be equipped with a 1.5T engine in the medium term, and a 2.0T engine is available.

Q4 e-tron

Audi will launch at least seven new cars this year-figure 4 "src =" https://x0.ifengimg.com/ucms/2022 _ 02/110372ba1151732952f90749c8cb04de4e687a824 _ size68 _ w680 _ h415.jpg ">

Audi will launch at least seven new cars this year-Figure 5 "src =" https://x0.ifengimg.com/ucms/2022 _ 02/8d07a49158c5b5ad73f9fefb455ea2ccd018e _ size69 _ w680 _ h415.jpg ">

Audi will launch at least seven new cars this year-Figure 6 "src =" https://x0.ifengimg.com/ucms/2022 _ 02/22fc7e2A8B28E2cF8c4315E8ED21C3E688A4Be9A _ size46 _ W680 _ H415.jpg ">

As its first pure electric vehicle based on MEB platform, Q4 e-tron is positioned as an A+ class SUV, and its overall size is close to that of ID.4 series. The new car adopts the e-tron family design language, and the interior layout is simple and has a good sense of science and technology. It is equipped with a 10.25-inch full LCD instrument and an 11.6-inch central control panel. In terms of power and cruising range, Q4 e-tron will provide three models with power and cruising range, and its main competitors in the future are.

Mid-term change to A8 family

Audi will launch at least seven new cars this year-figure 7 "src =" https://x0.ifengimg.com/ucms/2022 _ 02/5b1b11c 9010ff97220bf79f56b4f1738eeca8becb _ size48 _ w680 _ h415.jpg ">

Audi will launch at least seven new cars this year-figure 8 "src =" https://x0.ifengimg.com/ucms/2022 _ 02/99E7D19c63feffabf2265c0325aa196485c47cf _ size30 _ w680 _ h415.jpg ">

Audi will launch at least seven new cars this year-figure 9 "src =" https://x0.ifengimg.com/ucms/2022 _ 02/155163419f70eeecc6aa014797b 46d 450830c 589f _ size38 _ w680 _ h415.jpg ">

In the mid-term, the A8 family changed its design, especially the gas field in the front of the car is more powerful than the current model. The interior of the new car basically continues the design of the current model, and the Horch model specially launched for the China market further enhances the luxury of the whole car. In terms of power, the plug-in hybrid system consisting of 3.0T (high and low power) +48V light mixing system, 4.0T+48V light mixing system engine and 3.0T+ motor will continue to be equipped, while the A8L Horch will be equipped with 3.0T+48V light mixing system, and the transmission systems of the new car are all matched with 8AT gearboxes, and the quattro four-wheel drive system is standard.

E-tron GT family

Audi will launch at least seven new cars this year-figure 10 "src =" https://x0.ifengimg.com/ucms/2022 _ 02/c84bada60e52b58f2e75ef0dc58052b59c31 _ size44 _ w680 _ h396.jpg ">

Audi will launch at least seven new cars this year-Figure 11 "src =" https://x0.ifengimg.com/ucms/2022 _ 02/D948F946CD 26C6 E66243D1C1F1630CADA AD3496D _ Size46 _ W680 _ H396.JPG ">

Audi will launch at least seven new cars this year-figure 12 "src =" https://x0.ifengimg.com/ucms/2022 _ 02/275d8251a 546fc35824998487ad381ddf83ed8b2 _ size38 _ w680 _ h396.jpg ">

E-tron GT locates medium and large pure electric sports cars, which are built on the same J1 platform, and the body shape and size are also very close. E-tron GT quattro and RS e-tron GT are expected to be launched in China, with slightly different appearance and interior details. In terms of power, the e-tron GT quattro is equipped with front and rear dual motors, with a comprehensive maximum power of 350kW, an acceleration of 4.1 seconds per 100 kilometers and a cruising range of 488km；. The combined maximum power of RS e-tron GT is 440kW, the acceleration of 100 km is 3.3 seconds, and the cruising range of WLTP is 472km.

Mid-term change S8L

Audi will launch at least seven new cars this year-Figure 13 "src =" https://x0.ifengimg.com/ucms/2022 _ 02/A0CA18D2C 19942598F766339A001341B C5E7BC _ Size44 _ W680 _ H415.JPG ">

Audi will launch at least seven new cars this year-figure 14 "src =" https://x0.ifengimg.com/ucms/2022 _ 02/62ab60fa066743f31872d4c53dc4e111defd45 _ size43 _ w680 _ h415.jpg ">

Audi will launch at least seven new cars this year-figure 15 "src =" https://x0.ifengimg.com/ucms/2022 _ 02/bab977089a03301a020f 9f4f4e3c257b 988fa9807b _ size40 _ w680 _ h415.jpg ">

Like the A8 family, the S8L changed its design in the middle term, making the overall visual effect more sporty and continuing the title of suit thug. In terms of power, the S8L is modified in the middle term with a 4.0T+48V light-mixed engine, with a maximum power of 420kW and a peak torque of 800N m. The transmission is matched with 8AT gearbox and equipped with quattro four-wheel drive system, and the acceleration of 100 kilometers is only 3.8s.

New S4 Avant

Audi will launch at least seven new cars A6L this year, and those who want to change cars will wait-Figure 1 "src =" https://x0.ifengimg.com/ucms/2022 _ 02/2b8f2a4d7b0c5ac5ac556ae5aa6066E5b4e _ size40 _ w680 _ h396.jpg ".

Audi will launch at least seven new cars A6L this year, and those who want to change cars will wait-Figure 2 "src =" https://x0.ifengimg.com/ucms/2022 _ 02/79DA1877152FD47C37D10E6D29600CBCA433F3 _ size 49 _ W680 _ H396.

Audi will launch at least seven new cars A6L this year, and those who want to change cars will wait-Figure 3 "src =" https://x0.ifengimg.com/ucms/2022 _ 02/EC3F5D2B1b86055EC6144ACF750Ad0cd67d46052 _ size42 _ W680 _ H396.jpg.

According to previous news, the new S4 Avant will be introduced in the second half of this year, and the first batch of cars will be delivered at the end of the year at the earliest, but the current sedan S4 may be replaced. The appearance and interior of the new S4 Avant are basically the same as those of the S4 currently on sale. The most obvious difference is its body shape. The new car is equipped with a 3.0T engine, with an estimated maximum power of 260kW and a peak torque of 500 N m. The transmission system matches the 8AT gearbox and is equipped with a quattro four-wheel drive system.

HarmonyOS OS version 1.0 of IT House is on the shelves! Native development!

　 OS version 1.0 released!

Thanks to Peter of @ Soft Media Products Department, the all-platform products of IT House client have reached the next level, and HarmonyOS OS//IOS/PWA/UWP/WeChat applet/Baidu applet/Alipay applet /macOS/Chrome extension … IT House fully covers PC and mobile clients!

IT House-Strive to provide important value content in pan-technology and frontier fields as quickly and completely as possible. This is the orientation and mission of IT House. Since we want to explore the frontier forever, it is natural and inevitable to launch the native version of HarmonyOS OS App.

After the release of HarmonyOS OS, many questions were raised, saying that this system is a shell version, a self-help version and a fool version. However, people in the technology industry know that it is a low-level and leading-edge system. Although almost all operating systems in the world are of the same origin, the history of human development is to stand on the shoulders of predecessors. In the past, foreign guns were inseparable from Chinese gunpowder technology. I believe that with the continuous development of HarmonyOS OS, other giants will follow up and have followed up the advanced design ideas of HarmonyOS OS, and a new era of Internet of Everything and intelligence has arrived.

Pioneers will pay a great price to develop the native version of HarmonyOS OS App, because many places are really immature, but it is gratifying to watch this system make continuous iterative progress every day. Today, he will share IT with you in the IT number "Soft Media Ape" of the Soft Media Products Department. I believe that many lion ape students are also paying close attention to this. As a starting point, I also hope that the experts in the industry can share more in the comments or open the IT number!

At present, HarmonyOS OS version 1.0 of IT House has found some known bugs, such as the problem that the bottom menu bar on some devices can’t be displayed completely. We have made corrections in the internal version of 1.01, and please give us more feedback. As always, the soft media product department will follow up as soon as possible! Thank you!

Click here to install IT House HarmonyOS Edition > >

Or, search for "IT House" in the application market of HarmonyOS OS, click the search button, and look down for the IT House with HMOS logo in the results, and then install it. At present, the search ranking of HarmonyOS versions of various apps in Huawei’s application market is particularly low, and I believe Huawei will improve it in the future.

HarmonyOS OS version of IT House will also appear in the application area of HarmonyOS in the next step, so that everyone can find and discover it better.

Remember to give a five-star review in the store to support us to do better!


Scan the QR code or click here to download the latest version (automatically identify each platform).

Can also be downloaded separately:
IOS version | Win10/Win8 version | Android version | WP7/8 version

IT House (www.ithome.com), a fast, in-depth and rich report and evaluation of cutting-edge information of science and technology, IT industry and digital products. The whole platform (Android /iOS/ HarmonyOS OS/PWA/Win10/WP/ WeChat applet/Baidu applet /WP/macOS/Chrome) covers PC and mobile clients-akg, love it here.

▲ Overview of IT House HarmonyOS OS Edition Home Page

▲ The HarmonyOS version of the IT House, which was originally developed, is simple and simple.

▲IT House HarmonyOS OS Version 1.0 still joined the well-received "Discovery" column.

Scan the QR code or click here to download the latest version (automatic platform identification).

Can also be downloaded separately:
IOS version | Win10/Win8 version | Android version